A genome-wide association study of sporadic ALS in a homogenous Irish population

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive limb or bulbar weakness. Efforts to elucidate the disease-associated loci have to date produced conflicting results. One strategy to improve power in genome-wide studies is to genotype a genetically...

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Veröffentlicht in:	Human molecular genetics 2008-03, Vol.17 (5), p.768-774
Hauptverfasser:	Cronin, Simon, Berger, Stephen, Ding, Jinhui, Schymick, Jennifer C, Washecka, Nicole, Hernandez, Dena G., Greenway, Matthew J., Bradley, Daniel G., Traynor, Bryan J., Hardiman, Orla
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Biological and medical sciences Case-Control Studies Chromosome Mapping Chromosomes, Human, Pair 7 Cohort Studies Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Female Fundamental and applied biological sciences. Psychology Gene Frequency Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genetics, Population Genome, Human Humans Ireland - epidemiology Linkage Disequilibrium Lod Score Male Middle Aged Molecular and cellular biology Nerve Tissue Proteins - genetics Oligonucleotide Array Sequence Analysis Peptide Hydrolases - genetics Polymorphism, Single Nucleotide Potassium Channels - genetics Probability Statistics as Topic
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