Role of thrombin in interleukin-5 expression from basophils

Interleukin-5 (IL-5) plays a key role in the pathogenesis of bronchial asthma. Thrombin is a procoagulant factor that has been also reported to participate in the inflammatory response by stimulating the secretion of cytokines. Interaction of inflammatory cells with airway epithelial cells may also...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-03, Vol.368 (1), p.116-120
Hauptverfasser:	Yamaguchi, Aiko, Gabazza, Esteban C., Takei, Yoshiyuki, Yano, Yutaka, Fujimoto, Hajime, D’Alessandro-Gabazza, Corina N., Murakami, Eiko, Kobayashi, Tetsu, Takagi, Takehiro, Maruyama, Junko, Suzuki, Koji, Taguchi, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy Basophils - drug effects Basophils - metabolism Basophils - secretion Bronchial asthma Cell Line Coagulation Coculture Techniques Epithelial Cells - drug effects Epithelial Cells - secretion Humans Interleukin-5 Interleukin-5 - metabolism Interleukin-5 - secretion Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Kinase Inhibitors - pharmacology Receptors, Thrombin - metabolism Thrombin Thrombin - pharmacology
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