STAT3: A critical transcription activator in angiogenesis
Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important rol...
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| Veröffentlicht in: | Medicinal research reviews 2008-03, Vol.28 (2), p.185-200 |
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| description | Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well‐studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 185–200, 2008 |
| doi_str_mv | 10.1002/med.20101 |
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Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well‐studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF. © 2007 Wiley Periodicals, Inc. 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Med Res Rev, 28, No. 2, 185–200, 2008</description><subject>angiogenesis</subject><subject>Animals</subject><subject>Coronary Vessels - growth & development</subject><subject>Humans</subject><subject>interleukin-6</subject><subject>Neoplasms - blood supply</subject><subject>Neovascularization, Pathologic - physiopathology</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Signal Transduction</subject><subject>STAT3</subject><subject>STAT3 Transcription Factor - physiology</subject><subject>transcription factors</subject><subject>Transcriptional Activation - physiology</subject><subject>Vascular Endothelial Growth Factor A - biosynthesis</subject><subject>Vascular Endothelial Growth Factor A - physiology</subject><subject>VEGF</subject><issn>0198-6325</issn><issn>1098-1128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhC0EoqVw4AVQTkgcUrx2HDvcqlLKT1sOROJoGcepDGlS7BTo25OS0hvitDurb2alQegUcB8wJpcLk_UJBgx7qAs4ESEAEfuoi6HZY0pYBx15_4oxAAN6iDrAI8YFkC5KntJBSq-CQaCdra1WRVA7VfpGLWtblYHStf1QdeUC24hybqu5KY23_hgd5Krw5mQ7eyi9GaXD23DyOL4bDiahjpiAkCZCZ5Q0zwCrLMozEWnBKVWJyCnkWaaZ4YQyDhBDFEeC4DgDDkmcR8xo2kPnbezSVe8r42u5sF6bolClqVZeckwSJmL8L0iAcCYoNOBFC2pXee9MLpfOLpRbS8By06ds-pQ_fTbs2TZ09bK57shtgQ1w2QKftjDrv5PkdHT9Gxm2Dutr87VzKPcmY045k8-zsXxIBZ6K-0TO6Dcc84so</recordid><startdate>200803</startdate><enddate>200803</enddate><creator>Chen, Zhong</creator><creator>Han, Zhong Chao</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>200803</creationdate><title>STAT3: A critical transcription activator in angiogenesis</title><author>Chen, Zhong ; Han, Zhong Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4581-398cd3281210ad4fd84c8733a98f31fddc5e7235711614648206d17196f45ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>angiogenesis</topic><topic>Animals</topic><topic>Coronary Vessels - growth & development</topic><topic>Humans</topic><topic>interleukin-6</topic><topic>Neoplasms - blood supply</topic><topic>Neovascularization, Pathologic - physiopathology</topic><topic>Neovascularization, Physiologic - physiology</topic><topic>Signal Transduction</topic><topic>STAT3</topic><topic>STAT3 Transcription Factor - physiology</topic><topic>transcription factors</topic><topic>Transcriptional Activation - physiology</topic><topic>Vascular Endothelial Growth Factor A - biosynthesis</topic><topic>Vascular Endothelial Growth Factor A - physiology</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhong</creatorcontrib><creatorcontrib>Han, Zhong Chao</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Medicinal research reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhong</au><au>Han, Zhong Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STAT3: A critical transcription activator in angiogenesis</atitle><jtitle>Medicinal research reviews</jtitle><addtitle>Med. 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| fulltext | fulltext |
| identifier | ISSN: 0198-6325 |
| ispartof | Medicinal research reviews, 2008-03, Vol.28 (2), p.185-200 |
| issn | 0198-6325 1098-1128 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | angiogenesis Animals Coronary Vessels - growth & development Humans interleukin-6 Neoplasms - blood supply Neovascularization, Pathologic - physiopathology Neovascularization, Physiologic - physiology Signal Transduction STAT3 STAT3 Transcription Factor - physiology transcription factors Transcriptional Activation - physiology Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - physiology VEGF |
| title | STAT3: A critical transcription activator in angiogenesis |
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