A Novel Affinity-Based Controlled Release System Involving Derivatives of Dextran with Enhanced Osmotic Activity

Dextran is a highly biocompatible molecule with osmotic activity. We synthesized histidine derivatives of dextran, DexH (dextran histidine), to test the feasibility of an IMAC-based controlled release system. DexH was synthesized by the periodate oxidation method. The effect of periodate oxidation a...

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Veröffentlicht in:	Bioconjugate chemistry 2007-03, Vol.18 (2), p.477-483
Hauptverfasser:	Devakumar, Jyothi, Vijayalakshmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biochemistry Carbohydrates Chemical synthesis Chromatography, Affinity Copper - chemistry Copper - metabolism Delayed-Action Preparations Dextrans - chemistry Diffusion Edetic Acid - chemistry Edetic Acid - metabolism Feasibility Studies Histidine - chemistry Imino Acids - chemistry Imino Acids - metabolism Molecules Organometallic Compounds - chemistry Organometallic Compounds - metabolism Osmotic Pressure Zinc - chemistry Zinc - metabolism
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