Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks
Objectives To investigate the potential value of choroid plexus cyst, intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel as markers of trisomy 21 at 11 + 0 to 13 + 6 weeks. Methods We examined three‐dimensional volumes from 228 fetuses with trisomy 21 and 797 chromosomally normal...
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| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2008-02, Vol.31 (2), p.132-135 |
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| creator | Dagklis, T. Plasencia, W. Maiz, N. Duarte, L. Nicolaides, K. H. |
| description | Objectives
To investigate the potential value of choroid plexus cyst, intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel as markers of trisomy 21 at 11 + 0 to 13 + 6 weeks.
Methods
We examined three‐dimensional volumes from 228 fetuses with trisomy 21 and 797 chromosomally normal fetuses at 11 + 0 to 13 + 6 weeks of gestation. We looked for choroid plexus cysts with a minimum diameter of 1.5 mm, intracardiac echogenic focus, hydronephrosis with a minimum anteroposterior diameter of the pelvis of 1.5 mm and hyperechogenic bowel.
Results
The prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel was significantly higher in trisomy 21 than in normal fetuses (9.6% vs. 1.5%, 17.1% vs. 5.3% and 11.4% vs. 2.4%, respectively). There was no significant difference between the two groups in the prevalence of choroid plexus cysts (7.5% vs. 5.0%). There were no significant differences in crown–rump length or nuchal translucency thickness in either chromosomally normal or trisomy 21 fetuses between those with and those without any one of the markers.
Conclusions
At 11 + 0 to 13 + 6 weeks the prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel is higher in trisomy 21 than in chromosomally normal fetuses. As there is no significant association between the presence of these markers and nuchal translucency thickness, they could be included in the assessment of risk to improve accuracy of screening. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/uog.5224 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70294562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>19718749</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4144-a6f16626798a4f3a86415227538e85e10dcfa2703fa7beb46939048b816e8b323</originalsourceid><addsrcrecordid>eNqFkc9u1DAQhy0EokuLxBMgX0BINMX_YjtHtIKCVKkXeo4cZ7JryMbBk2jJW_DI9XZX9FRxsuX5_BvNfIS84eyKMyY-zXFzVQqhnpEVV7oqmGHlc7JilWaF0ZU4I68QfzLGtJL6JTnjltmyFGZF_q63McXQ0rGHPzNSv-B0ScMwJeddaoPzFPw2bmAInnbRz3hJt8sI6fG1iXvoqRvaXGhTHGDcpogBcwpFnyBDwyb_TXRKAeNuoYJTN1HO6UfK6BQpl_mm6R7gF16QF53rEV6fznNy9_XLj_W34ub2-vv6803hFVeqcLrjWgttKutUJ53ViucNmFJasCVw1vrOCcNk50wDTV6KrJiyjeUabCOFPCfvj7ljir9nwKneBfTQ926AOGNtmKhUqf8P8spwa1SVwQ9H0OfxMUFXjynsXFpqzuqDpjprqg-aMvr2lDk3O2gfwZOXDLw7AQ6967vkBh_wHyeyyVLIQ1Bx5Pahh-XJhvXd7fVD43t5g6cW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19718749</pqid></control><display><type>article</type><title>Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB Electronic Journals Library</source><creator>Dagklis, T. ; Plasencia, W. ; Maiz, N. ; Duarte, L. ; Nicolaides, K. H.</creator><creatorcontrib>Dagklis, T. ; Plasencia, W. ; Maiz, N. ; Duarte, L. ; Nicolaides, K. H.</creatorcontrib><description>Objectives
To investigate the potential value of choroid plexus cyst, intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel as markers of trisomy 21 at 11 + 0 to 13 + 6 weeks.
Methods
We examined three‐dimensional volumes from 228 fetuses with trisomy 21 and 797 chromosomally normal fetuses at 11 + 0 to 13 + 6 weeks of gestation. We looked for choroid plexus cysts with a minimum diameter of 1.5 mm, intracardiac echogenic focus, hydronephrosis with a minimum anteroposterior diameter of the pelvis of 1.5 mm and hyperechogenic bowel.
Results
The prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel was significantly higher in trisomy 21 than in normal fetuses (9.6% vs. 1.5%, 17.1% vs. 5.3% and 11.4% vs. 2.4%, respectively). There was no significant difference between the two groups in the prevalence of choroid plexus cysts (7.5% vs. 5.0%). There were no significant differences in crown–rump length or nuchal translucency thickness in either chromosomally normal or trisomy 21 fetuses between those with and those without any one of the markers.
Conclusions
At 11 + 0 to 13 + 6 weeks the prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel is higher in trisomy 21 than in chromosomally normal fetuses. As there is no significant association between the presence of these markers and nuchal translucency thickness, they could be included in the assessment of risk to improve accuracy of screening. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.5224</identifier><identifier>PMID: 18085527</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Biological and medical sciences ; Brain Diseases - diagnostic imaging ; Brain Diseases - embryology ; cardiac echogenic focus ; Cardiomyopathies - diagnostic imaging ; Cardiomyopathies - embryology ; Choroid Plexus - diagnostic imaging ; Choroid Plexus - embryology ; choroid plexus cysts ; Chromosome aberrations ; Crown-Rump Length ; Cysts - diagnostic imaging ; Cysts - embryology ; Down Syndrome - diagnostic imaging ; echogenic bowel ; Female ; Fetal Diseases - diagnostic imaging ; first‐trimester screening ; Gynecology. Andrology. Obstetrics ; Humans ; hydronephrosis ; Hydronephrosis - diagnostic imaging ; Hydronephrosis - embryology ; Intestinal Diseases - diagnostic imaging ; Intestinal Diseases - embryology ; Kidneys ; Medical genetics ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nuchal Translucency Measurement ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; trisomy 21 ; Ultrasonography, Prenatal ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Ultrasound in obstetrics & gynecology, 2008-02, Vol.31 (2), p.132-135</ispartof><rights>Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</rights><rights>2008 INIST-CNRS</rights><rights>Copyright (c) 2007 ISUOG. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4144-a6f16626798a4f3a86415227538e85e10dcfa2703fa7beb46939048b816e8b323</citedby><cites>FETCH-LOGICAL-c4144-a6f16626798a4f3a86415227538e85e10dcfa2703fa7beb46939048b816e8b323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fuog.5224$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fuog.5224$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20065234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18085527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dagklis, T.</creatorcontrib><creatorcontrib>Plasencia, W.</creatorcontrib><creatorcontrib>Maiz, N.</creatorcontrib><creatorcontrib>Duarte, L.</creatorcontrib><creatorcontrib>Nicolaides, K. H.</creatorcontrib><title>Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>Objectives
To investigate the potential value of choroid plexus cyst, intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel as markers of trisomy 21 at 11 + 0 to 13 + 6 weeks.
Methods
We examined three‐dimensional volumes from 228 fetuses with trisomy 21 and 797 chromosomally normal fetuses at 11 + 0 to 13 + 6 weeks of gestation. We looked for choroid plexus cysts with a minimum diameter of 1.5 mm, intracardiac echogenic focus, hydronephrosis with a minimum anteroposterior diameter of the pelvis of 1.5 mm and hyperechogenic bowel.
Results
The prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel was significantly higher in trisomy 21 than in normal fetuses (9.6% vs. 1.5%, 17.1% vs. 5.3% and 11.4% vs. 2.4%, respectively). There was no significant difference between the two groups in the prevalence of choroid plexus cysts (7.5% vs. 5.0%). There were no significant differences in crown–rump length or nuchal translucency thickness in either chromosomally normal or trisomy 21 fetuses between those with and those without any one of the markers.
Conclusions
At 11 + 0 to 13 + 6 weeks the prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel is higher in trisomy 21 than in chromosomally normal fetuses. As there is no significant association between the presence of these markers and nuchal translucency thickness, they could be included in the assessment of risk to improve accuracy of screening. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - diagnostic imaging</subject><subject>Brain Diseases - embryology</subject><subject>cardiac echogenic focus</subject><subject>Cardiomyopathies - diagnostic imaging</subject><subject>Cardiomyopathies - embryology</subject><subject>Choroid Plexus - diagnostic imaging</subject><subject>Choroid Plexus - embryology</subject><subject>choroid plexus cysts</subject><subject>Chromosome aberrations</subject><subject>Crown-Rump Length</subject><subject>Cysts - diagnostic imaging</subject><subject>Cysts - embryology</subject><subject>Down Syndrome - diagnostic imaging</subject><subject>echogenic bowel</subject><subject>Female</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>first‐trimester screening</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>hydronephrosis</subject><subject>Hydronephrosis - diagnostic imaging</subject><subject>Hydronephrosis - embryology</subject><subject>Intestinal Diseases - diagnostic imaging</subject><subject>Intestinal Diseases - embryology</subject><subject>Kidneys</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nuchal Translucency Measurement</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Second</subject><subject>trisomy 21</subject><subject>Ultrasonography, Prenatal</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EokuLxBMgX0BINMX_YjtHtIKCVKkXeo4cZ7JryMbBk2jJW_DI9XZX9FRxsuX5_BvNfIS84eyKMyY-zXFzVQqhnpEVV7oqmGHlc7JilWaF0ZU4I68QfzLGtJL6JTnjltmyFGZF_q63McXQ0rGHPzNSv-B0ScMwJeddaoPzFPw2bmAInnbRz3hJt8sI6fG1iXvoqRvaXGhTHGDcpogBcwpFnyBDwyb_TXRKAeNuoYJTN1HO6UfK6BQpl_mm6R7gF16QF53rEV6fznNy9_XLj_W34ub2-vv6803hFVeqcLrjWgttKutUJ53ViucNmFJasCVw1vrOCcNk50wDTV6KrJiyjeUabCOFPCfvj7ljir9nwKneBfTQ926AOGNtmKhUqf8P8spwa1SVwQ9H0OfxMUFXjynsXFpqzuqDpjprqg-aMvr2lDk3O2gfwZOXDLw7AQ6967vkBh_wHyeyyVLIQ1Bx5Pahh-XJhvXd7fVD43t5g6cW</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Dagklis, T.</creator><creator>Plasencia, W.</creator><creator>Maiz, N.</creator><creator>Duarte, L.</creator><creator>Nicolaides, K. H.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200802</creationdate><title>Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks</title><author>Dagklis, T. ; Plasencia, W. ; Maiz, N. ; Duarte, L. ; Nicolaides, K. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4144-a6f16626798a4f3a86415227538e85e10dcfa2703fa7beb46939048b816e8b323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Brain Diseases - diagnostic imaging</topic><topic>Brain Diseases - embryology</topic><topic>cardiac echogenic focus</topic><topic>Cardiomyopathies - diagnostic imaging</topic><topic>Cardiomyopathies - embryology</topic><topic>Choroid Plexus - diagnostic imaging</topic><topic>Choroid Plexus - embryology</topic><topic>choroid plexus cysts</topic><topic>Chromosome aberrations</topic><topic>Crown-Rump Length</topic><topic>Cysts - diagnostic imaging</topic><topic>Cysts - embryology</topic><topic>Down Syndrome - diagnostic imaging</topic><topic>echogenic bowel</topic><topic>Female</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>first‐trimester screening</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>hydronephrosis</topic><topic>Hydronephrosis - diagnostic imaging</topic><topic>Hydronephrosis - embryology</topic><topic>Intestinal Diseases - diagnostic imaging</topic><topic>Intestinal Diseases - embryology</topic><topic>Kidneys</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nuchal Translucency Measurement</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Second</topic><topic>trisomy 21</topic><topic>Ultrasonography, Prenatal</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dagklis, T.</creatorcontrib><creatorcontrib>Plasencia, W.</creatorcontrib><creatorcontrib>Maiz, N.</creatorcontrib><creatorcontrib>Duarte, L.</creatorcontrib><creatorcontrib>Nicolaides, K. H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dagklis, T.</au><au>Plasencia, W.</au><au>Maiz, N.</au><au>Duarte, L.</au><au>Nicolaides, K. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2008-02</date><risdate>2008</risdate><volume>31</volume><issue>2</issue><spage>132</spage><epage>135</epage><pages>132-135</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><abstract>Objectives
To investigate the potential value of choroid plexus cyst, intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel as markers of trisomy 21 at 11 + 0 to 13 + 6 weeks.
Methods
We examined three‐dimensional volumes from 228 fetuses with trisomy 21 and 797 chromosomally normal fetuses at 11 + 0 to 13 + 6 weeks of gestation. We looked for choroid plexus cysts with a minimum diameter of 1.5 mm, intracardiac echogenic focus, hydronephrosis with a minimum anteroposterior diameter of the pelvis of 1.5 mm and hyperechogenic bowel.
Results
The prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel was significantly higher in trisomy 21 than in normal fetuses (9.6% vs. 1.5%, 17.1% vs. 5.3% and 11.4% vs. 2.4%, respectively). There was no significant difference between the two groups in the prevalence of choroid plexus cysts (7.5% vs. 5.0%). There were no significant differences in crown–rump length or nuchal translucency thickness in either chromosomally normal or trisomy 21 fetuses between those with and those without any one of the markers.
Conclusions
At 11 + 0 to 13 + 6 weeks the prevalence of intracardiac echogenic focus, hydronephrosis and hyperechogenic bowel is higher in trisomy 21 than in chromosomally normal fetuses. As there is no significant association between the presence of these markers and nuchal translucency thickness, they could be included in the assessment of risk to improve accuracy of screening. Copyright © 2007 ISUOG. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18085527</pmid><doi>10.1002/uog.5224</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Ultrasound in obstetrics & gynecology, 2008-02, Vol.31 (2), p.132-135 |
| issn | 0960-7692 1469-0705 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB Electronic Journals Library |
| subjects | Adult Biological and medical sciences Brain Diseases - diagnostic imaging Brain Diseases - embryology cardiac echogenic focus Cardiomyopathies - diagnostic imaging Cardiomyopathies - embryology Choroid Plexus - diagnostic imaging Choroid Plexus - embryology choroid plexus cysts Chromosome aberrations Crown-Rump Length Cysts - diagnostic imaging Cysts - embryology Down Syndrome - diagnostic imaging echogenic bowel Female Fetal Diseases - diagnostic imaging first‐trimester screening Gynecology. Andrology. Obstetrics Humans hydronephrosis Hydronephrosis - diagnostic imaging Hydronephrosis - embryology Intestinal Diseases - diagnostic imaging Intestinal Diseases - embryology Kidneys Medical genetics Medical sciences Middle Aged Nephrology. Urinary tract diseases Nuchal Translucency Measurement Predictive Value of Tests Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second trisomy 21 Ultrasonography, Prenatal Urinary system involvement in other diseases. Miscellaneous |
| title | Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks |
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