Sphingosine-1-phosphate signaling in the cardiovascular system
Increasing evidence suggests a key role for the bioactive lipid sphingosine-1-phosphate (S1P) and its G-protein-coupled receptors (S1P1–5 ) in the cardiovascular system. Recent advances in sphingolipid research indicates that cardiomyocyte, vascular smooth muscle and endothelial cell function is gre...
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| Veröffentlicht in: | Current opinion in pharmacology 2007-04, Vol.7 (2), p.186-192 |
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| creator | Peters, Stephan LM Alewijnse, Astrid E |
| description | Increasing evidence suggests a key role for the bioactive lipid sphingosine-1-phosphate (S1P) and its G-protein-coupled receptors (S1P1–5 ) in the cardiovascular system. Recent advances in sphingolipid research indicates that cardiomyocyte, vascular smooth muscle and endothelial cell function is greatly influenced by the relative expression and activity both of S1P receptors and of the enzymes involved in sphingolipid metabolism. For instance, the discovery and development of S1P receptor agonists such as FTY720 has clearly indicated the involvement of S1P receptors in the regulation of heart rate. In addition, sphingolipid metabolism induced, for example, by tumour necrosis factor-α or angiotensin II plays an important role in vessel structure, function and tone. |
| doi_str_mv | 10.1016/j.coph.2006.09.008 |
| format | Article |
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| identifier | ISSN: 1471-4892 |
| ispartof | Current opinion in pharmacology, 2007-04, Vol.7 (2), p.186-192 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cardiovascular Physiological Phenomena Drug Design Endothelial Cells - metabolism Humans Internal Medicine Lysophospholipids - metabolism Medical Education Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocytes, Cardiac - metabolism Receptors, Lysosphingolipid - agonists Receptors, Lysosphingolipid - antagonists & inhibitors Receptors, Lysosphingolipid - metabolism Signal Transduction Sphingolipids - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism |
| title | Sphingosine-1-phosphate signaling in the cardiovascular system |
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