Inhibitory Gli3 Activity Negatively Regulates Wnt/β-Catenin Signaling

The Hedgehog (Hh) and Wingless (Wnt) families of secreted signaling molecules have key roles in embryonic development and adult tissue homeostasis [1–3]. In the developing neural tube, Wnt and Shh, emanating from dorsal and ventral regions, respectively, have been proposed to govern the proliferatio...

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Veröffentlicht in:	Current biology 2007-03, Vol.17 (6), p.545-550
Hauptverfasser:	Ulloa, Fausto, Itasaki, Nobue, Briscoe, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - antagonists & inhibitors beta Catenin - metabolism Chick Embryo DEVBIO Embryo, Mammalian - metabolism Embryo, Nonmammalian - metabolism Embryonic Development Gene Expression Regulation Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Protein Interaction Mapping Signal Transduction Wnt Proteins - antagonists & inhibitors Wnt Proteins - genetics Wnt Proteins - metabolism Wnt3 Protein Xenopus Zinc Finger Protein Gli3
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