Characterization of resistance mutations against HCV ketoamide protease inhibitors

An issue of clinical importance in the development of new antivirals for HCV is emergence of resistance. Several resistance loci to ketoamide inhibitors of the NS3/4A protease have been identified (residues V36, T54, R155, A156, and V170) by replicon and clinical studies. Using SCH 567312, a more po...

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Veröffentlicht in:	Antiviral research 2008-03, Vol.77 (3), p.177-185
Hauptverfasser:	Tong, Xiao, Bogen, Stephane, Chase, Robert, Girijavallabhan, V., Guo, Zhuyan, Njoroge, F. George, Prongay, Andrew, Saksena, Anil, Skelton, Angela, Xia, Ellen, Ralston, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Boceprevir Carrier Proteins - metabolism Drug Resistance, Viral HCV replicon Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - physiology Hepatitis C virus Humans Medical sciences Models, Molecular Molecular Structure Mutation, Missense Oligopeptides - pharmacology Pharmacology. Drug treatments Proline - analogs & derivatives Proline - pharmacology Protease Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Resistance mutation SCH 503034 Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism Viral Proteins - metabolism Virus Replication - physiology
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