Surfactant-polymer nanoparticles : A novel platform for sustained and enhanced cellular delivery of water-soluble molecules

Nanoparticles, drug carriers in the sub-micron size range, can enhance the therapeutic efficacy of encapsulated drug by increasing and sustaining the delivery of the drug inside the cell. However, the use of nanoparticles for small molecular weight, water-soluble drugs has been limited by poor drug...

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Veröffentlicht in:	Pharmaceutical research 2007-04, Vol.24 (4), p.803-810
Hauptverfasser:	CHAVANPATIL, Mahesh D, KHDAIR, Ayman, PANYAM, Jayanth
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Alginates - chemistry Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Antineoplastic agents Biological and medical sciences Breast cancer Cell culture Cell Line, Tumor Cell Membrane - metabolism Cell Survival - drug effects Chemistry, Pharmaceutical Delayed-Action Preparations Dioctyl Sulfosuccinic Acid - chemistry Doxorubicin - chemistry Doxorubicin - metabolism Doxorubicin - pharmacology Drug Carriers Drug Compounding Effectiveness Exocytosis General aspects General pharmacology Glucuronic Acid - chemistry Hexuronic Acids - chemistry Humans Kinetics Medical sciences Molecular Weight Nanoparticles Particle Size Pharmaceutical industry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - chemistry R&D Research & development Rhodamines - chemistry Rhodamines - metabolism Solubility Surface-Active Agents - chemistry Technology, Pharmaceutical - methods Time Factors Water - chemistry
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