Aberrant epigenetic patterns in the etiology of gastrointestinal cancers
A body of evidence accumulated over the past decade suggests that epigenetic mechanisms play an essential role in maintaining important cellular functions. Changes in epigenetic patterns (mainly DNA hyper- and hypomethylation and, more recently, histone modifications) may contribute to the developme...
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| Veröffentlicht in: | Journal of applied genetics 2008-01, Vol.49 (1), p.1-10 |
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| container_title | Journal of applied genetics |
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| creator | Karpiński, Paweł Sąsiadek, Maria M. Blin, Nikolaus |
| description | A body of evidence accumulated over the past decade suggests that epigenetic mechanisms play an essential role in maintaining important cellular functions. Changes in epigenetic patterns (mainly DNA hyper- and hypomethylation and, more recently, histone modifications) may contribute to the development of cancer. Aberrant epigenetic events expand thorough tumor progression from the earliest to latest stages, therefore they can serve as convenient markers for detection and prognosis of cancer. The potential reversibility of epigenetic states in the tumor cell is an attractive target for cancer therapy. Much of our current knowledge on epigenetic alternations in cancer comes from studies on gastrointestinal malignancies, mainly on colorectal cancer, which currently serves as a model for epigenetic tumorigenesis. This review summarizes the current knowledge of epigenetic changes in gastrointestinal cancers and how this relates directly to disease progression and prognosis. |
| doi_str_mv | 10.1007/BF03195243 |
| format | Article |
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Changes in epigenetic patterns (mainly DNA hyper- and hypomethylation and, more recently, histone modifications) may contribute to the development of cancer. Aberrant epigenetic events expand thorough tumor progression from the earliest to latest stages, therefore they can serve as convenient markers for detection and prognosis of cancer. The potential reversibility of epigenetic states in the tumor cell is an attractive target for cancer therapy. Much of our current knowledge on epigenetic alternations in cancer comes from studies on gastrointestinal malignancies, mainly on colorectal cancer, which currently serves as a model for epigenetic tumorigenesis. 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Sąsiadek, Maria M. ; Blin, Nikolaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-3cdf384e56852f41f983211f4fc8551bceb9908e86e64a20a78c8298b83f97753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Alternations</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer</topic><topic>Colorectal carcinoma</topic><topic>Deoxyribonucleic acid</topic><topic>Disease Progression</topic><topic>DNA</topic><topic>DNA Methylation</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Epigenetics</topic><topic>Etiology</topic><topic>Gastrointestinal Neoplasms - etiology</topic><topic>Gastrointestinal Neoplasms - genetics</topic><topic>Gastrointestinal Neoplasms - metabolism</topic><topic>Histones</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Invited Editorial</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Plant Genetics and Genomics</topic><topic>Prognosis</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karpiński, Paweł</creatorcontrib><creatorcontrib>Sąsiadek, Maria M.</creatorcontrib><creatorcontrib>Blin, Nikolaus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karpiński, Paweł</au><au>Sąsiadek, Maria M.</au><au>Blin, Nikolaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant epigenetic patterns in the etiology of gastrointestinal cancers</atitle><jtitle>Journal of applied genetics</jtitle><stitle>J Appl Genet</stitle><addtitle>J Appl Genet</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>49</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1234-1983</issn><eissn>2190-3883</eissn><abstract>A body of evidence accumulated over the past decade suggests that epigenetic mechanisms play an essential role in maintaining important cellular functions. 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| subjects | Alternations Animal Genetics and Genomics Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Cancer Colorectal carcinoma Deoxyribonucleic acid Disease Progression DNA DNA Methylation Epigenesis, Genetic - genetics Epigenetics Etiology Gastrointestinal Neoplasms - etiology Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Histones Human Genetics Humans Invited Editorial Life Sciences Microbial Genetics and Genomics Plant Genetics and Genomics Prognosis Tumorigenesis Tumors |
| title | Aberrant epigenetic patterns in the etiology of gastrointestinal cancers |
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