Polymorphisms in Toll-Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis
Toll-like receptors (TLRs) are important components of innate immunity.Weinvestigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4...
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| Veröffentlicht in: | The Journal of infectious diseases 2008-02, Vol.197 (4), p.618-621 |
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| container_title | The Journal of infectious diseases |
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| creator | Carvalho, A. Pasqualotto, A. C. Pitzurra, L. Romani, L. Denning, D. W. Rodrigues, F. |
| description | Toll-like receptors (TLRs) are important components of innate immunity.Weinvestigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P = .003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P = .043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis. |
| doi_str_mv | 10.1086/526500 |
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C.</creatorcontrib><creatorcontrib>Pitzurra, L.</creatorcontrib><creatorcontrib>Romani, L.</creatorcontrib><creatorcontrib>Denning, D. W.</creatorcontrib><creatorcontrib>Rodrigues, F.</creatorcontrib><title>Polymorphisms in Toll-Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Toll-like receptors (TLRs) are important components of innate immunity.Weinvestigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P = .003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P = .043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.</description><subject>Aged</subject><subject>Alleles</subject><subject>Allergic Bronchopulmonary</subject><subject>Allergic bronchopulmonary aspergillosis</subject><subject>Aspergillosis</subject><subject>Aspergillosis - genetics</subject><subject>Aspergillosis - immunology</subject><subject>Aspergillosis, Allergic Bronchopulmonary - genetics</subject><subject>Aspergillosis, Allergic Bronchopulmonary - immunology</subject><subject>Aspergillus</subject><subject>Aspergillus fumigatus</subject><subject>Aspergillus fumigatus - immunology</subject><subject>Aspergillus fumigatus - pathogenicity</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fungal</subject><subject>Fungi</subject><subject>Gene frequency</subject><subject>Genotypes</subject><subject>Human mycoses</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lung Diseases</subject><subject>Lung Diseases, Fungal - genetics</subject><subject>Lung Diseases, Fungal - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycoses</subject><subject>Mycoses of the respiratory system</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pulmonary aspergillosis</subject><subject>Receptors</subject><subject>Science & Technology</subject><subject>Single Nucleotide</subject><subject>Toll like receptors</subject><subject>Toll-Like Receptor 2 - genetics</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Toll-Like Receptor 9 - genetics</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U2P0zAQBuAIgdiywD8AmQPcAmM7tpPjqsAWqKCCRUVcLMeZgnedONgJov-eVKkKF8TJkufRq_nIsocUnlMo5QvBpAC4lS2o4CqXkvLb2QKAsZyWVXWW3UvpGgAKLtXd7IyWTAlWwiLbboLftyH2311qE3EduQre52t3g-QjWuyHEMkldpiI6RryaUyHP1c774Y9GQLZjL4NnYl7cpF6jN-c9yG5dD-7szM-4YPje559fv3qarnK1x8u3ywv1rkVhRpyU0oEW4vdzmJTgiywqiWvAC2dOq1rLJngliOt60ZJLGTDOK2hLmyBQvGSn2fP5tw-hh8jpkG3bmrRe9NhGJNWwCoQEv4LaSWhoOqvRBtDShF3uo-unQbUFPRh13re9QQfHxPHusXmDzsudwJPj8Aka_wums66dHIMKOdKVpMjs4vWmF5H_OnSYNIhiGlJCyEn8mQmYez_3c-j2Vyn6WgnxQFKJcvDYPlcn9Lx16lu4o2WiiuhV1--6uVq8_b9y-1Wv-O_AZnPs5c</recordid><startdate>20080215</startdate><enddate>20080215</enddate><creator>Carvalho, A.</creator><creator>Pasqualotto, A. C.</creator><creator>Pitzurra, L.</creator><creator>Romani, L.</creator><creator>Denning, D. W.</creator><creator>Rodrigues, F.</creator><general>The University Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>RCLKO</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080215</creationdate><title>Polymorphisms in Toll-Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis</title><author>Carvalho, A. ; Pasqualotto, A. C. ; Pitzurra, L. ; Romani, L. ; Denning, D. W. ; Rodrigues, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-a86e0cb5ffced8064e9b6390ec1367bbe8253c3e1bbd76e46d231b0b4c4e57383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>Allergic Bronchopulmonary</topic><topic>Allergic bronchopulmonary aspergillosis</topic><topic>Aspergillosis</topic><topic>Aspergillosis - genetics</topic><topic>Aspergillosis - immunology</topic><topic>Aspergillosis, Allergic Bronchopulmonary - genetics</topic><topic>Aspergillosis, Allergic Bronchopulmonary - immunology</topic><topic>Aspergillus</topic><topic>Aspergillus fumigatus</topic><topic>Aspergillus fumigatus - immunology</topic><topic>Aspergillus fumigatus - pathogenicity</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fungal</topic><topic>Fungi</topic><topic>Gene frequency</topic><topic>Genotypes</topic><topic>Human mycoses</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lung Diseases</topic><topic>Lung Diseases, Fungal - genetics</topic><topic>Lung Diseases, Fungal - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycoses</topic><topic>Mycoses of the respiratory system</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pulmonary aspergillosis</topic><topic>Receptors</topic><topic>Science & Technology</topic><topic>Single Nucleotide</topic><topic>Toll like receptors</topic><topic>Toll-Like Receptor 2 - genetics</topic><topic>Toll-Like Receptor 4 - genetics</topic><topic>Toll-Like Receptor 9 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carvalho, A.</creatorcontrib><creatorcontrib>Pasqualotto, A. C.</creatorcontrib><creatorcontrib>Pitzurra, L.</creatorcontrib><creatorcontrib>Romani, L.</creatorcontrib><creatorcontrib>Denning, D. 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C.</au><au>Pitzurra, L.</au><au>Romani, L.</au><au>Denning, D. W.</au><au>Rodrigues, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms in Toll-Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2008-02-15</date><risdate>2008</risdate><volume>197</volume><issue>4</issue><spage>618</spage><epage>621</epage><pages>618-621</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Toll-like receptors (TLRs) are important components of innate immunity.Weinvestigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P = .003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P = .043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.</abstract><cop>Chicago, IL</cop><pub>The University Chicago Press</pub><pmid>18275280</pmid><doi>10.1086/526500</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Alleles Allergic Bronchopulmonary Allergic bronchopulmonary aspergillosis Aspergillosis Aspergillosis - genetics Aspergillosis - immunology Aspergillosis, Allergic Bronchopulmonary - genetics Aspergillosis, Allergic Bronchopulmonary - immunology Aspergillus Aspergillus fumigatus Aspergillus fumigatus - immunology Aspergillus fumigatus - pathogenicity Asthma Biological and medical sciences Case-Control Studies Cohort Studies Female Fungal Fungi Gene frequency Genotypes Human mycoses Humans Infectious diseases Lung Diseases Lung Diseases, Fungal - genetics Lung Diseases, Fungal - immunology Male Medical sciences Middle Aged Mycoses Mycoses of the respiratory system Polymorphism Polymorphism, Single Nucleotide Pulmonary aspergillosis Receptors Science & Technology Single Nucleotide Toll like receptors Toll-Like Receptor 2 - genetics Toll-Like Receptor 4 - genetics Toll-Like Receptor 9 - genetics |
| title | Polymorphisms in Toll-Like Receptor Genes and Susceptibility to Pulmonary Aspergillosis |
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