Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms
1 Dipartimento Farmaco-Biologico, Facoltà di Farmacia, Università degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy 2 Direzione Ricerca, Sviluppo & Innovazione, SIFI SpA, Via Ercole Patti 36, Lavinaio, 95020 Catania, Italy 3 Dipartimento di Chimica Bioorganica e Biofarmacia, Uni...
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| Veröffentlicht in: | Journal of medical microbiology 2007-04, Vol.56 (4), p.519-523 |
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| container_title | Journal of medical microbiology |
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| creator | Nostro, Antonia Roccaro, Andrea Sudano Bisignano, Giuseppe Marino, Andreana Cannatelli, Maria A Pizzimenti, Francesco C Cioni, Pier Luigi Procopio, Francesca Blanco, Anna Rita |
| description | 1 Dipartimento Farmaco-Biologico, Facoltà di Farmacia, Università degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
2 Direzione Ricerca, Sviluppo & Innovazione, SIFI SpA, Via Ercole Patti 36, Lavinaio, 95020 Catania, Italy
3 Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy
Correspondence Antonia Nostro atnostro{at}pharma.unime.it
Received 27 June 2006
Accepted 18 December 2006
The aim of this study was to evaluate the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus ( n =6) and S. epidermidis ( n =6) strains tested, the biofilm inhibitory concentration (0.1250.500 %, v/v, for oregano, and 0.0310.125 %, v/v, for carvacrol and thymol) and biofilm eradication concentration (0.251.0 %, v/v, for oregano and 0.1250.500 %, v/v, for carvacrol and thymol) values were twofold or fourfold greater than the concentration required to inhibit planktonic growth. Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates.
Abbreviations: BEC, biofilm eradication concentration; BIC, biofilm inhibitory concentration; MBC, minimum bactericidal concentration. |
| doi_str_mv | 10.1099/jmm.0.46804-0 |
| format | Article |
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2 Direzione Ricerca, Sviluppo & Innovazione, SIFI SpA, Via Ercole Patti 36, Lavinaio, 95020 Catania, Italy
3 Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy
Correspondence Antonia Nostro atnostro{at}pharma.unime.it
Received 27 June 2006
Accepted 18 December 2006
The aim of this study was to evaluate the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus ( n =6) and S. epidermidis ( n =6) strains tested, the biofilm inhibitory concentration (0.1250.500 %, v/v, for oregano, and 0.0310.125 %, v/v, for carvacrol and thymol) and biofilm eradication concentration (0.251.0 %, v/v, for oregano and 0.1250.500 %, v/v, for carvacrol and thymol) values were twofold or fourfold greater than the concentration required to inhibit planktonic growth. Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates.
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2 Direzione Ricerca, Sviluppo & Innovazione, SIFI SpA, Via Ercole Patti 36, Lavinaio, 95020 Catania, Italy
3 Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy
Correspondence Antonia Nostro atnostro{at}pharma.unime.it
Received 27 June 2006
Accepted 18 December 2006
The aim of this study was to evaluate the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus ( n =6) and S. epidermidis ( n =6) strains tested, the biofilm inhibitory concentration (0.1250.500 %, v/v, for oregano, and 0.0310.125 %, v/v, for carvacrol and thymol) and biofilm eradication concentration (0.251.0 %, v/v, for oregano and 0.1250.500 %, v/v, for carvacrol and thymol) values were twofold or fourfold greater than the concentration required to inhibit planktonic growth. Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates.
Abbreviations: BEC, biofilm eradication concentration; BIC, biofilm inhibitory concentration; MBC, minimum bactericidal concentration.</description><subject>Bacteriology</subject><subject>Biofilms - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cymenes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Monoterpenes - pharmacology</subject><subject>Oils, Volatile - pharmacology</subject><subject>Origanum</subject><subject>Plant Oils - pharmacology</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - ultrastructure</subject><subject>Staphylococcus epidermidis</subject><subject>Staphylococcus epidermidis - drug effects</subject><subject>Thymol - pharmacology</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c9PwyAUB3BiNDqnR6-mF_ViJxQK5WiW-SMx8aCeCaWwYUqZ0Gr230vdEhMvnh4Jnzwe3wfAGYIzBDm_eXduBmeEVpDkcA9MEGE4Lykh-2ACYVHkBUXlETiO8R1CxDDmh-AoVUYqTibALozRqo-ZN5kPeik7f50pGT6lCr7NZNdk_Wrj0tF32Usv16tN65VXaoiZHIIeSzJ_bvTaNjo429iY1dYb27p4Ag6MbKM-3dUpeLtbvM4f8qfn-8f57VOu0kR9zkxT0QJVGkuFJK5JUUBWE00JZ7TmCCulaKUMazBRhCBoKMOIlZhrlEiBp-By23cd_MegYy-cjUq3rey0H6JgsKhSG_YvRJxiTlmVYL6FKZIYgzZiHayTYSMQFOMSRFqCgOJnCQImf75rPNRON796l3oCFzsgo5KtCbJTNv66avzSj7vaupVdrr5s0GKpO2fTGCnU8dGSCiJKxPE3HrWeRQ</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Nostro, Antonia</creator><creator>Roccaro, Andrea Sudano</creator><creator>Bisignano, Giuseppe</creator><creator>Marino, Andreana</creator><creator>Cannatelli, Maria A</creator><creator>Pizzimenti, Francesco C</creator><creator>Cioni, Pier Luigi</creator><creator>Procopio, Francesca</creator><creator>Blanco, Anna Rita</creator><general>Soc General Microbiol</general><general>Society for General Microbiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms</title><author>Nostro, Antonia ; Roccaro, Andrea Sudano ; Bisignano, Giuseppe ; Marino, Andreana ; Cannatelli, Maria A ; Pizzimenti, Francesco C ; Cioni, Pier Luigi ; Procopio, Francesca ; Blanco, Anna Rita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-7fd86218e3ac1a3b42207b4e64976b913ccc68cf7d34c4410f67317539e149723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Bacteriology</topic><topic>Biofilms - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cymenes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Monoterpenes - pharmacology</topic><topic>Oils, Volatile - pharmacology</topic><topic>Origanum</topic><topic>Plant Oils - pharmacology</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - ultrastructure</topic><topic>Staphylococcus epidermidis</topic><topic>Staphylococcus epidermidis - drug effects</topic><topic>Thymol - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nostro, Antonia</creatorcontrib><creatorcontrib>Roccaro, Andrea Sudano</creatorcontrib><creatorcontrib>Bisignano, Giuseppe</creatorcontrib><creatorcontrib>Marino, Andreana</creatorcontrib><creatorcontrib>Cannatelli, Maria A</creatorcontrib><creatorcontrib>Pizzimenti, Francesco C</creatorcontrib><creatorcontrib>Cioni, Pier Luigi</creatorcontrib><creatorcontrib>Procopio, Francesca</creatorcontrib><creatorcontrib>Blanco, Anna Rita</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nostro, Antonia</au><au>Roccaro, Andrea Sudano</au><au>Bisignano, Giuseppe</au><au>Marino, Andreana</au><au>Cannatelli, Maria A</au><au>Pizzimenti, Francesco C</au><au>Cioni, Pier Luigi</au><au>Procopio, Francesca</au><au>Blanco, Anna Rita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms</atitle><jtitle>Journal of medical microbiology</jtitle><addtitle>J Med Microbiol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>56</volume><issue>4</issue><spage>519</spage><epage>523</epage><pages>519-523</pages><issn>0022-2615</issn><eissn>1473-5644</eissn><coden>JMMIAV</coden><abstract>1 Dipartimento Farmaco-Biologico, Facoltà di Farmacia, Università degli Studi di Messina, Villaggio Annunziata, 98168 Messina, Italy
2 Direzione Ricerca, Sviluppo & Innovazione, SIFI SpA, Via Ercole Patti 36, Lavinaio, 95020 Catania, Italy
3 Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy
Correspondence Antonia Nostro atnostro{at}pharma.unime.it
Received 27 June 2006
Accepted 18 December 2006
The aim of this study was to evaluate the effect of oregano essential oil, carvacrol and thymol on biofilm-grown Staphylococcus aureus and Staphylococcus epidermidis strains, as well as the effects of the oils on biofilm formation. For most of the S. aureus ( n =6) and S. epidermidis ( n =6) strains tested, the biofilm inhibitory concentration (0.1250.500 %, v/v, for oregano, and 0.0310.125 %, v/v, for carvacrol and thymol) and biofilm eradication concentration (0.251.0 %, v/v, for oregano and 0.1250.500 %, v/v, for carvacrol and thymol) values were twofold or fourfold greater than the concentration required to inhibit planktonic growth. Subinhibitory concentrations of the oils attenuated biofilm formation of S. aureus and S. epidermidis strains on polystyrene microtitre plates.
Abbreviations: BEC, biofilm eradication concentration; BIC, biofilm inhibitory concentration; MBC, minimum bactericidal concentration.</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>17374894</pmid><doi>10.1099/jmm.0.46804-0</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Bacteriology Biofilms - drug effects Biological and medical sciences Cymenes Fundamental and applied biological sciences. Psychology Infectious diseases Medical sciences Microbial Sensitivity Tests Microbiology Miscellaneous Monoterpenes - pharmacology Oils, Volatile - pharmacology Origanum Plant Oils - pharmacology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - ultrastructure Staphylococcus epidermidis Staphylococcus epidermidis - drug effects Thymol - pharmacology |
| title | Effects of oregano, carvacrol and thymol on Staphylococcus aureus and Staphylococcus epidermidis biofilms |
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