Rational drug design in parasitology: trans-sialidase as a case study for Chagas disease

Trypanosoma cruzi trans-sialidase is a potential target for Chagas disease chemotherapy. From the specific need of T. cruzi to obtain sialic acid through trans-sialidase-mediated transfers from host sources and the lack of alternative to this for the parasite, a good case can be made for T. cruzi tr...

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Veröffentlicht in:	Drug discovery today 2008-02, Vol.13 (3), p.110-117
Hauptverfasser:	Neres, João, Bryce, Richard A., Douglas, Kenneth T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Biological and medical sciences Chagas Disease - drug therapy Chagas Disease - enzymology Chagas Disease - pathology Drug Design Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology General pharmacology Glycoproteins - antagonists & inhibitors Glycoproteins - metabolism Humans Medical sciences Molecular Structure Neuraminidase - antagonists & inhibitors Neuraminidase - metabolism Parasitology - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology
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