Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA

Anterior tibial translation associated with posterior impingement has been reported to be one of the factors limiting flexion after posterior cruciate-retaining (CR) total knee arthroplasty (TKA), especially when posterior condylar offset is decreased postoperatively. On the other hand, its effect o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2008-01, Vol.13 (1), p.46-50
Hauptverfasser: Arabori, Motoya, Matsui, Nobuzo, Kuroda, Ryosuke, Mizuno, Kiyonori, Doita, Minoru, Kurosaka, Masahiro, Yoshiya, Shinichi
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 50
container_issue 1
container_start_page 46
container_title Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
container_volume 13
creator Arabori, Motoya
Matsui, Nobuzo
Kuroda, Ryosuke
Mizuno, Kiyonori
Doita, Minoru
Kurosaka, Masahiro
Yoshiya, Shinichi
description Anterior tibial translation associated with posterior impingement has been reported to be one of the factors limiting flexion after posterior cruciate-retaining (CR) total knee arthroplasty (TKA), especially when posterior condylar offset is decreased postoperatively. On the other hand, its effect on postoperative motion in posterior-stabilized (PS) TKA remains unknown. It has been demonstrated that PS TKA exhibits a consistent posterior femoral rollback during flexion. Thus, we hypothesized that the problem of posterior impingement can be avoided by use of PS TKA. In this study, we examined the relationship between postoperative posterior condylar offset and knee flexion in CR and PS TKAs. In this study, analysis was performed for 20 subjects who underwent bilateral TKAs (one CR and one PS TKA) as well as another group of 50 PS TKAs. All patients could be tracked for a minimum of 2 years. The range of flexion was measured before operation and at follow-up. Preoperative and postoperative posterior condylar offset was evaluated on true lateral radiographs. At the follow-up examination, the mean flexion angle was 123° in the CR knees and 131° in the PS knees with a significantly greater improvement observed for the latter group. In the roentgenographic measurement of the posterior condylar offset, no significant difference was observed between the preoperative and postoperative values both in the CR and PS knees. We divided the patients into two groups according to the change of posterior condylar offset. The first group (Group I) showed a decrease in the posterior condylar offset after surgery and the second group (Group II) showed no change or an increase. Subsequently, postoperative change in flexion was compared between Groups I and II for the CR and PS knees. A significant difference between Groups I and II was observed in the CR knees, while no difference was observed in the PS knees. The magnitude of postoperative posterior condylar offset did not correlate with an improvement in maximum flexion angle in the 50 PS knees. It was shown that the magnitude of posterior condylar offset correlated with a postoperative change in flexion angle in CR knees, while no such correlation was observed in PS knees.
doi_str_mv 10.1007/s00776-007-1191-5
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70288867</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0949265815323095</els_id><sourcerecordid>70288867</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-adb9ed71545abe04aa30eb787c1151bf7b541fb25ff26182c9567cbe34a7f7d03</originalsourceid><addsrcrecordid>eNp9kE9rHCEYhyU0NJukHyCXMvTQm4k64zhDT8vSpiWB5JCcxT-vwTCrW50p3Xz6uJ2FhR728ir4_H7qg9AVJdeUEHGTyxAtLhNT2lPMT9CCNnWLGWH1B7QgfdNj1vLuDJ3n_EoIFbznH9EZ7ZhoOs4XSD_GPELyMVUmBrsdVKqicxnGSgVbuQH--hgqH6rNAUyT8WoEnGBUPvjw8o89AHlU2g_-DWz1dLe8RKdODRk-7dcL9Pzj-9PqJ75_uP21Wt5jwxsyYmV1D1ZQ3nClgTRK1QS06IShlFPthOYNdZpx51hbPmB63gqjoW6UcMKS-gJ9nXs3Kf6eII9y7bOBYVAB4pSlIKzrulYU8Mt_4GucUihvk4yRnnLS1gWiM2RSzDmBk5vk1yptJSVyZ1_O9uVuu7Mvecl83hdPeg32kNjrLgCbgVyOwgukw83HWr_NISjy_vgSysZDMGB9AjNKG_2R9Ds0WqQn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220915063</pqid></control><display><type>article</type><title>Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Arabori, Motoya ; Matsui, Nobuzo ; Kuroda, Ryosuke ; Mizuno, Kiyonori ; Doita, Minoru ; Kurosaka, Masahiro ; Yoshiya, Shinichi</creator><creatorcontrib>Arabori, Motoya ; Matsui, Nobuzo ; Kuroda, Ryosuke ; Mizuno, Kiyonori ; Doita, Minoru ; Kurosaka, Masahiro ; Yoshiya, Shinichi</creatorcontrib><description>Anterior tibial translation associated with posterior impingement has been reported to be one of the factors limiting flexion after posterior cruciate-retaining (CR) total knee arthroplasty (TKA), especially when posterior condylar offset is decreased postoperatively. On the other hand, its effect on postoperative motion in posterior-stabilized (PS) TKA remains unknown. It has been demonstrated that PS TKA exhibits a consistent posterior femoral rollback during flexion. Thus, we hypothesized that the problem of posterior impingement can be avoided by use of PS TKA. In this study, we examined the relationship between postoperative posterior condylar offset and knee flexion in CR and PS TKAs. In this study, analysis was performed for 20 subjects who underwent bilateral TKAs (one CR and one PS TKA) as well as another group of 50 PS TKAs. All patients could be tracked for a minimum of 2 years. The range of flexion was measured before operation and at follow-up. Preoperative and postoperative posterior condylar offset was evaluated on true lateral radiographs. At the follow-up examination, the mean flexion angle was 123° in the CR knees and 131° in the PS knees with a significantly greater improvement observed for the latter group. In the roentgenographic measurement of the posterior condylar offset, no significant difference was observed between the preoperative and postoperative values both in the CR and PS knees. We divided the patients into two groups according to the change of posterior condylar offset. The first group (Group I) showed a decrease in the posterior condylar offset after surgery and the second group (Group II) showed no change or an increase. Subsequently, postoperative change in flexion was compared between Groups I and II for the CR and PS knees. A significant difference between Groups I and II was observed in the CR knees, while no difference was observed in the PS knees. The magnitude of postoperative posterior condylar offset did not correlate with an improvement in maximum flexion angle in the 50 PS knees. It was shown that the magnitude of posterior condylar offset correlated with a postoperative change in flexion angle in CR knees, while no such correlation was observed in PS knees.</description><identifier>ISSN: 0949-2658</identifier><identifier>EISSN: 1436-2023</identifier><identifier>DOI: 10.1007/s00776-007-1191-5</identifier><identifier>PMID: 18274855</identifier><language>eng</language><publisher>Tokyo: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Knee - adverse effects ; Arthroplasty, Replacement, Knee - methods ; Cohort Studies ; Female ; Humans ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; Original Article ; Orthopedics ; Osteoarthritis, Knee - diagnostic imaging ; Osteoarthritis, Knee - physiopathology ; Osteoarthritis, Knee - surgery ; Posterior Cruciate Ligament - surgery ; Radiography ; Range of Motion, Articular - physiology ; Recovery of Function - physiology ; Retrospective Studies ; Rheumatology ; Treatment Outcome</subject><ispartof>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2008-01, Vol.13 (1), p.46-50</ispartof><rights>2008 The Japanese Orthopaedic Association</rights><rights>The Japanese Orthopaedic Association 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-adb9ed71545abe04aa30eb787c1151bf7b541fb25ff26182c9567cbe34a7f7d03</citedby><cites>FETCH-LOGICAL-c540t-adb9ed71545abe04aa30eb787c1151bf7b541fb25ff26182c9567cbe34a7f7d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00776-007-1191-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00776-007-1191-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18274855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arabori, Motoya</creatorcontrib><creatorcontrib>Matsui, Nobuzo</creatorcontrib><creatorcontrib>Kuroda, Ryosuke</creatorcontrib><creatorcontrib>Mizuno, Kiyonori</creatorcontrib><creatorcontrib>Doita, Minoru</creatorcontrib><creatorcontrib>Kurosaka, Masahiro</creatorcontrib><creatorcontrib>Yoshiya, Shinichi</creatorcontrib><title>Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA</title><title>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</title><addtitle>J Orthop Sci</addtitle><addtitle>J Orthop Sci</addtitle><description>Anterior tibial translation associated with posterior impingement has been reported to be one of the factors limiting flexion after posterior cruciate-retaining (CR) total knee arthroplasty (TKA), especially when posterior condylar offset is decreased postoperatively. On the other hand, its effect on postoperative motion in posterior-stabilized (PS) TKA remains unknown. It has been demonstrated that PS TKA exhibits a consistent posterior femoral rollback during flexion. Thus, we hypothesized that the problem of posterior impingement can be avoided by use of PS TKA. In this study, we examined the relationship between postoperative posterior condylar offset and knee flexion in CR and PS TKAs. In this study, analysis was performed for 20 subjects who underwent bilateral TKAs (one CR and one PS TKA) as well as another group of 50 PS TKAs. All patients could be tracked for a minimum of 2 years. The range of flexion was measured before operation and at follow-up. Preoperative and postoperative posterior condylar offset was evaluated on true lateral radiographs. At the follow-up examination, the mean flexion angle was 123° in the CR knees and 131° in the PS knees with a significantly greater improvement observed for the latter group. In the roentgenographic measurement of the posterior condylar offset, no significant difference was observed between the preoperative and postoperative values both in the CR and PS knees. We divided the patients into two groups according to the change of posterior condylar offset. The first group (Group I) showed a decrease in the posterior condylar offset after surgery and the second group (Group II) showed no change or an increase. Subsequently, postoperative change in flexion was compared between Groups I and II for the CR and PS knees. A significant difference between Groups I and II was observed in the CR knees, while no difference was observed in the PS knees. The magnitude of postoperative posterior condylar offset did not correlate with an improvement in maximum flexion angle in the 50 PS knees. It was shown that the magnitude of posterior condylar offset correlated with a postoperative change in flexion angle in CR knees, while no such correlation was observed in PS knees.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthroplasty, Replacement, Knee - adverse effects</subject><subject>Arthroplasty, Replacement, Knee - methods</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Posterior Cruciate Ligament - surgery</subject><subject>Radiography</subject><subject>Range of Motion, Articular - physiology</subject><subject>Recovery of Function - physiology</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>Treatment Outcome</subject><issn>0949-2658</issn><issn>1436-2023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE9rHCEYhyU0NJukHyCXMvTQm4k64zhDT8vSpiWB5JCcxT-vwTCrW50p3Xz6uJ2FhR728ir4_H7qg9AVJdeUEHGTyxAtLhNT2lPMT9CCNnWLGWH1B7QgfdNj1vLuDJ3n_EoIFbznH9EZ7ZhoOs4XSD_GPELyMVUmBrsdVKqicxnGSgVbuQH--hgqH6rNAUyT8WoEnGBUPvjw8o89AHlU2g_-DWz1dLe8RKdODRk-7dcL9Pzj-9PqJ75_uP21Wt5jwxsyYmV1D1ZQ3nClgTRK1QS06IShlFPthOYNdZpx51hbPmB63gqjoW6UcMKS-gJ9nXs3Kf6eII9y7bOBYVAB4pSlIKzrulYU8Mt_4GucUihvk4yRnnLS1gWiM2RSzDmBk5vk1yptJSVyZ1_O9uVuu7Mvecl83hdPeg32kNjrLgCbgVyOwgukw83HWr_NISjy_vgSysZDMGB9AjNKG_2R9Ds0WqQn</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Arabori, Motoya</creator><creator>Matsui, Nobuzo</creator><creator>Kuroda, Ryosuke</creator><creator>Mizuno, Kiyonori</creator><creator>Doita, Minoru</creator><creator>Kurosaka, Masahiro</creator><creator>Yoshiya, Shinichi</creator><general>Elsevier B.V</general><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA</title><author>Arabori, Motoya ; Matsui, Nobuzo ; Kuroda, Ryosuke ; Mizuno, Kiyonori ; Doita, Minoru ; Kurosaka, Masahiro ; Yoshiya, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-adb9ed71545abe04aa30eb787c1151bf7b541fb25ff26182c9567cbe34a7f7d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthroplasty, Replacement, Knee - adverse effects</topic><topic>Arthroplasty, Replacement, Knee - methods</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Posterior Cruciate Ligament - surgery</topic><topic>Radiography</topic><topic>Range of Motion, Articular - physiology</topic><topic>Recovery of Function - physiology</topic><topic>Retrospective Studies</topic><topic>Rheumatology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arabori, Motoya</creatorcontrib><creatorcontrib>Matsui, Nobuzo</creatorcontrib><creatorcontrib>Kuroda, Ryosuke</creatorcontrib><creatorcontrib>Mizuno, Kiyonori</creatorcontrib><creatorcontrib>Doita, Minoru</creatorcontrib><creatorcontrib>Kurosaka, Masahiro</creatorcontrib><creatorcontrib>Yoshiya, Shinichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arabori, Motoya</au><au>Matsui, Nobuzo</au><au>Kuroda, Ryosuke</au><au>Mizuno, Kiyonori</au><au>Doita, Minoru</au><au>Kurosaka, Masahiro</au><au>Yoshiya, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA</atitle><jtitle>Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association</jtitle><stitle>J Orthop Sci</stitle><addtitle>J Orthop Sci</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>13</volume><issue>1</issue><spage>46</spage><epage>50</epage><pages>46-50</pages><issn>0949-2658</issn><eissn>1436-2023</eissn><abstract>Anterior tibial translation associated with posterior impingement has been reported to be one of the factors limiting flexion after posterior cruciate-retaining (CR) total knee arthroplasty (TKA), especially when posterior condylar offset is decreased postoperatively. On the other hand, its effect on postoperative motion in posterior-stabilized (PS) TKA remains unknown. It has been demonstrated that PS TKA exhibits a consistent posterior femoral rollback during flexion. Thus, we hypothesized that the problem of posterior impingement can be avoided by use of PS TKA. In this study, we examined the relationship between postoperative posterior condylar offset and knee flexion in CR and PS TKAs. In this study, analysis was performed for 20 subjects who underwent bilateral TKAs (one CR and one PS TKA) as well as another group of 50 PS TKAs. All patients could be tracked for a minimum of 2 years. The range of flexion was measured before operation and at follow-up. Preoperative and postoperative posterior condylar offset was evaluated on true lateral radiographs. At the follow-up examination, the mean flexion angle was 123° in the CR knees and 131° in the PS knees with a significantly greater improvement observed for the latter group. In the roentgenographic measurement of the posterior condylar offset, no significant difference was observed between the preoperative and postoperative values both in the CR and PS knees. We divided the patients into two groups according to the change of posterior condylar offset. The first group (Group I) showed a decrease in the posterior condylar offset after surgery and the second group (Group II) showed no change or an increase. Subsequently, postoperative change in flexion was compared between Groups I and II for the CR and PS knees. A significant difference between Groups I and II was observed in the CR knees, while no difference was observed in the PS knees. The magnitude of postoperative posterior condylar offset did not correlate with an improvement in maximum flexion angle in the 50 PS knees. It was shown that the magnitude of posterior condylar offset correlated with a postoperative change in flexion angle in CR knees, while no such correlation was observed in PS knees.</abstract><cop>Tokyo</cop><pub>Elsevier B.V</pub><pmid>18274855</pmid><doi>10.1007/s00776-007-1191-5</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0949-2658
ispartof Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2008-01, Vol.13 (1), p.46-50
issn 0949-2658
1436-2023
language eng
recordid cdi_proquest_miscellaneous_70288867
source MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings
subjects Aged
Aged, 80 and over
Arthroplasty, Replacement, Knee - adverse effects
Arthroplasty, Replacement, Knee - methods
Cohort Studies
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Orthopedics
Osteoarthritis, Knee - diagnostic imaging
Osteoarthritis, Knee - physiopathology
Osteoarthritis, Knee - surgery
Posterior Cruciate Ligament - surgery
Radiography
Range of Motion, Articular - physiology
Recovery of Function - physiology
Retrospective Studies
Rheumatology
Treatment Outcome
title Posterior condylar offset and flexion in posterior cruciate-retaining and posterior stabilized TKA
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T16%3A17%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Posterior%20condylar%20offset%20and%20flexion%20in%20posterior%20cruciate-retaining%20and%20posterior%20stabilized%20TKA&rft.jtitle=Journal%20of%20orthopaedic%20science%20:%20official%20journal%20of%20the%20Japanese%20Orthopaedic%20Association&rft.au=Arabori,%20Motoya&rft.date=2008-01-01&rft.volume=13&rft.issue=1&rft.spage=46&rft.epage=50&rft.pages=46-50&rft.issn=0949-2658&rft.eissn=1436-2023&rft_id=info:doi/10.1007/s00776-007-1191-5&rft_dat=%3Cproquest_cross%3E70288867%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220915063&rft_id=info:pmid/18274855&rft_els_id=S0949265815323095&rfr_iscdi=true