CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) is a key component in endoplasmic reticulum (ER) stress-mediated apoptosis. The goal of the study was to investigate the role of CHOP in cholestatic liver injury. Acute liver injury and liver fibrosis were assessed in wild-type (WT) an...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2008-02, Vol.294 (2), p.G498-G505
Hauptverfasser:	Tamaki, Nobuyuki, Hatano, Etsuro, Taura, Kojiro, Tada, Masaharu, Kodama, Yuzo, Nitta, Takashi, Iwaisako, Keiko, Seo, Satoru, Nakajima, Akio, Ikai, Iwao, Uemoto, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Bile Biochemistry Blotting, Western Caspase 3 - biosynthesis Caspase 3 - genetics CCAAT-Enhancer-Binding Proteins - physiology Cells Cells, Cultured Cholagogues and Choleretics - pharmacology Cholestasis - complications Cholestasis - genetics Cholestasis - pathology Cystic fibrosis Endoplasmic Reticulum - pathology Glycochenodeoxycholic Acid - pharmacology Hepatocytes - pathology Hepatology Immunohistochemistry Ligation Liver Liver - pathology Liver Cirrhosis - etiology Liver Cirrhosis - genetics Liver Cirrhosis - pathology Mice Mice, Inbred C57BL Mice, Knockout Necrosis Proteins Reverse Transcriptase Polymerase Chain Reaction Transforming Growth Factor beta1 - physiology
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