Determination of lovastatin in human plasma by ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study
A selective, rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the quantitative determination of lovastatin in human plasma and its application in a pharmacokinetic study. With mycophenolate mofetil as internal standard, sample...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2008-03, Vol.46 (4), p.808-813 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
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| creator | Yuan, Haiyan Wang, Feng Tu, Jiying Peng, Wenxing Li, Huande |
| description | A selective, rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the quantitative determination of lovastatin in human plasma and its application in a pharmacokinetic study. With mycophenolate mofetil as internal standard, sample pretreatment involved a one-step extraction with
tert-butyl methyl ether of 0.2
ml plasma. The analysis was carried out on an ACQUITY UPLCTM BEH C18 column (50
mm
×
2.1
mm, i.d., 1.7
μm) with flow rate of 0.35
ml/min. The mobile phase was 20% water and 80% acetonitrile (v/v). The detection was performed on a triple-quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI). Linear calibration curves were obtained in the concentration range of 0.08–24.50
ng/ml, with a lower limit of quantification of 0.08
ng/ml. The intra- and inter-day precision (RSD) values were below 15% and accuracy (RE) was −7.6 to 9.3% at all QC levels. The method was applicable to clinical pharmacokinetic study of lovastatin in healthy volunteers following oral administration. |
| doi_str_mv | 10.1016/j.jpba.2007.12.005 |
| format | Article |
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tert-butyl methyl ether of 0.2
ml plasma. The analysis was carried out on an ACQUITY UPLCTM BEH C18 column (50
mm
×
2.1
mm, i.d., 1.7
μm) with flow rate of 0.35
ml/min. The mobile phase was 20% water and 80% acetonitrile (v/v). The detection was performed on a triple-quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI). Linear calibration curves were obtained in the concentration range of 0.08–24.50
ng/ml, with a lower limit of quantification of 0.08
ng/ml. The intra- and inter-day precision (RSD) values were below 15% and accuracy (RE) was −7.6 to 9.3% at all QC levels. The method was applicable to clinical pharmacokinetic study of lovastatin in healthy volunteers following oral administration.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2007.12.005</identifier><identifier>PMID: 18206330</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Chromatography, Liquid - methods ; Determination ; Drug Stability ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Human plasma ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood ; Lovastatin ; Lovastatin - blood ; Lovastatin - chemistry ; Lovastatin - pharmacokinetics ; Medical sciences ; Pharmacokinetic ; Pharmacology. Drug treatments ; Quality Control ; Spectrometry, Mass, Electrospray Ionization - methods ; Tandem Mass Spectrometry ; UPLC–ESI-MS/MS</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2008-03, Vol.46 (4), p.808-813</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-104112e2e6b813b7edb120e888fecdc5e2fad2170166d5bd12646aad5472f26f3</citedby><cites>FETCH-LOGICAL-c384t-104112e2e6b813b7edb120e888fecdc5e2fad2170166d5bd12646aad5472f26f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0731708507007388$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20137179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18206330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Haiyan</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Tu, Jiying</creatorcontrib><creatorcontrib>Peng, Wenxing</creatorcontrib><creatorcontrib>Li, Huande</creatorcontrib><title>Determination of lovastatin in human plasma by ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>A selective, rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the quantitative determination of lovastatin in human plasma and its application in a pharmacokinetic study. With mycophenolate mofetil as internal standard, sample pretreatment involved a one-step extraction with
tert-butyl methyl ether of 0.2
ml plasma. The analysis was carried out on an ACQUITY UPLCTM BEH C18 column (50
mm
×
2.1
mm, i.d., 1.7
μm) with flow rate of 0.35
ml/min. The mobile phase was 20% water and 80% acetonitrile (v/v). The detection was performed on a triple-quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI). Linear calibration curves were obtained in the concentration range of 0.08–24.50
ng/ml, with a lower limit of quantification of 0.08
ng/ml. The intra- and inter-day precision (RSD) values were below 15% and accuracy (RE) was −7.6 to 9.3% at all QC levels. The method was applicable to clinical pharmacokinetic study of lovastatin in healthy volunteers following oral administration.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - methods</subject><subject>Determination</subject><subject>Drug Stability</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Human plasma</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood</subject><subject>Lovastatin</subject><subject>Lovastatin - blood</subject><subject>Lovastatin - chemistry</subject><subject>Lovastatin - pharmacokinetics</subject><subject>Medical sciences</subject><subject>Pharmacokinetic</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality Control</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Tandem Mass Spectrometry</subject><subject>UPLC–ESI-MS/MS</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFSEQhYnROHdGX8CFYaO7boH-ncSNGR01mcSNJu5INVR7udINA_Qk7cp38GV8Hp9Ern2jOxMSAnx1qjiHkCeclZzx9sWhPPgBSsFYV3JRMtbcIzved1Uh2vrzfbJjXcWLjvXNGTmP8cAywS_rh-SM94K1VcV25OdrTBgmM0MybqZupNbdQUz5ONO89ssEM_UW4gR0WOliU4DCYxhdyC8KqTW3i9FU7YObILkvAfx-_fX9B1pUKbjoA6w0a5tvW4sEs8aJThAjjf4PM2EKK8331KRIwXtr1AbnCYD6PeReyn01MyajaEyLXh-RByPYiI9P-wX5dP3m49W74ubD2_dXr24KVfV1KjirORcosB16Xg0d6oELhn3fj6i0alCMoAXvsp-tbgbNs3UtgG7qToyiHasL8nzT9cHdLhiTnExUaC3M6JYoOyb6ltVtBsUGqvzpGHCUPpgJwio5k8e85EEe85LHvCQXMqeRi56e1JdhQv2v5BRQBp6dAIgK7Biy5yb-5QTjVce7y8y93DjMXtwZDDIqgzkfbUL2WGpn_jfHbz84u14</recordid><startdate>20080313</startdate><enddate>20080313</enddate><creator>Yuan, Haiyan</creator><creator>Wang, Feng</creator><creator>Tu, Jiying</creator><creator>Peng, Wenxing</creator><creator>Li, Huande</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080313</creationdate><title>Determination of lovastatin in human plasma by ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study</title><author>Yuan, Haiyan ; Wang, Feng ; Tu, Jiying ; Peng, Wenxing ; Li, Huande</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-104112e2e6b813b7edb120e888fecdc5e2fad2170166d5bd12646aad5472f26f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Liquid - methods</topic><topic>Determination</topic><topic>Drug Stability</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Human plasma</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood</topic><topic>Lovastatin</topic><topic>Lovastatin - blood</topic><topic>Lovastatin - chemistry</topic><topic>Lovastatin - pharmacokinetics</topic><topic>Medical sciences</topic><topic>Pharmacokinetic</topic><topic>Pharmacology. Drug treatments</topic><topic>Quality Control</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Tandem Mass Spectrometry</topic><topic>UPLC–ESI-MS/MS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Haiyan</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Tu, Jiying</creatorcontrib><creatorcontrib>Peng, Wenxing</creatorcontrib><creatorcontrib>Li, Huande</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Haiyan</au><au>Wang, Feng</au><au>Tu, Jiying</au><au>Peng, Wenxing</au><au>Li, Huande</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of lovastatin in human plasma by ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2008-03-13</date><risdate>2008</risdate><volume>46</volume><issue>4</issue><spage>808</spage><epage>813</epage><pages>808-813</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>A selective, rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the quantitative determination of lovastatin in human plasma and its application in a pharmacokinetic study. With mycophenolate mofetil as internal standard, sample pretreatment involved a one-step extraction with
tert-butyl methyl ether of 0.2
ml plasma. The analysis was carried out on an ACQUITY UPLCTM BEH C18 column (50
mm
×
2.1
mm, i.d., 1.7
μm) with flow rate of 0.35
ml/min. The mobile phase was 20% water and 80% acetonitrile (v/v). The detection was performed on a triple-quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) mode via electrospray ionization (ESI). Linear calibration curves were obtained in the concentration range of 0.08–24.50
ng/ml, with a lower limit of quantification of 0.08
ng/ml. The intra- and inter-day precision (RSD) values were below 15% and accuracy (RE) was −7.6 to 9.3% at all QC levels. The method was applicable to clinical pharmacokinetic study of lovastatin in healthy volunteers following oral administration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18206330</pmid><doi>10.1016/j.jpba.2007.12.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, Liquid - methods Determination Drug Stability Fundamental and applied biological sciences. Psychology General pharmacology Human plasma Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood Lovastatin Lovastatin - blood Lovastatin - chemistry Lovastatin - pharmacokinetics Medical sciences Pharmacokinetic Pharmacology. Drug treatments Quality Control Spectrometry, Mass, Electrospray Ionization - methods Tandem Mass Spectrometry UPLC–ESI-MS/MS |
| title | Determination of lovastatin in human plasma by ultra-performance liquid chromatography–electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study |
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