Centrally and Peripherally Administered Ghrelin Potently Inhibits Water Intake in Rats
Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after wat...
Gespeichert in:
| Veröffentlicht in: | Endocrinology (Philadelphia) 2007-04, Vol.148 (4), p.1638-1647 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1647 |
|---|---|
| container_issue | 4 |
| container_start_page | 1638 |
| container_title | Endocrinology (Philadelphia) |
| container_volume | 148 |
| creator | Hashimoto, Hirofumi Fujihara, Hiroaki Kawasaki, Makoto Saito, Takeshi Shibata, Minori Otsubo, Hiroki Takei, Yoshio Ueta, Yoichi |
| description | Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after water deprivation was significantly inhibited by icv injection of ghrelin (0.1, 1, and 10 nmol/rat) in a dose-related manner, although food intake was stimulated by the hormone. The antidipsogenic effect was as potent as the orexigenic effect. Similarly, water intake was inhibited, whereas food intake was stimulated dose dependently after iv injection of ghrelin (0.1, 1, and 10 nmol/kg). The inhibition of drinking was comparable with, or even more potent than, atrial natriuretic peptide (ANP), an established antidipsogenic hormone, when administered icv, although the antidipsogenic effect lasted longer. ANP had no effect on food intake. Urine volume decreased dose relatedly after icv injection of ghrelin but not by ANP. Intravenous injection of ghrelin had no effect on urine volume. Because drinking usually occurs with feeding, food was withdrawn to remove the prandial drinking. Then the antidipsogenic effect of ghrelin became more potent than that of ANP and continued longer than when food was available. Expression of Fos was increased in the area postrema and the nucleus of the tractus solitarius by using immunohistochemistry after icv and iv injection of ghrelin. The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats. |
| doi_str_mv | 10.1210/en.2006-0993 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70283868</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/en.2006-0993</oup_id><sourcerecordid>70283868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c520t-549c30bef375be781dfe4e0f771018f308362ee1fafd0f9d515514ad87c707d23</originalsourceid><addsrcrecordid>eNqF0Utr3DAQAGBRGppt2lvPxVDaXup0JFmWfAxLmwYCCaGPo9BaI1apV3Yk-5B_HxkbFkpLT2KkTzMaDSFvKJxTRuEzhnMGUJfQNPwZ2dCmEqWkEp6TDQDlpWRMnpKXKd3nsKoq_oKcUsmEYNBsyM8thjGarnssTLDFLUY_7HHZuLAHH3waMaItLvcROx-K237MN_LpVdj7nR9T8ctkkcPR_MYiizszplfkxJku4et1PSM_vn75vv1WXt9cXm0vrss2lx9LUTUthx06LsUOpaLWYYXgpKRAleOgeM0QqTPOgmusoELQylglWwnSMn5GPix5h9g_TJhGffCpxa4zAfspaQlMcVWr_0La1PkT6yrDd3_A-36KITehOeUgVEPZrD4tqo19ShGdHqI_mPioKeh5LBqDnsei57Fk_nZNOu0OaI94nUMG71dgUms6F01ofTo6VQsm6jnRx8X10_CvkuVaki8Sg-3b6AMOEVM6dvPXhz4BWI6w3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3130589124</pqid></control><display><type>article</type><title>Centrally and Peripherally Administered Ghrelin Potently Inhibits Water Intake in Rats</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hashimoto, Hirofumi ; Fujihara, Hiroaki ; Kawasaki, Makoto ; Saito, Takeshi ; Shibata, Minori ; Otsubo, Hiroki ; Takei, Yoshio ; Ueta, Yoichi</creator><creatorcontrib>Hashimoto, Hirofumi ; Fujihara, Hiroaki ; Kawasaki, Makoto ; Saito, Takeshi ; Shibata, Minori ; Otsubo, Hiroki ; Takei, Yoshio ; Ueta, Yoichi</creatorcontrib><description>Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after water deprivation was significantly inhibited by icv injection of ghrelin (0.1, 1, and 10 nmol/rat) in a dose-related manner, although food intake was stimulated by the hormone. The antidipsogenic effect was as potent as the orexigenic effect. Similarly, water intake was inhibited, whereas food intake was stimulated dose dependently after iv injection of ghrelin (0.1, 1, and 10 nmol/kg). The inhibition of drinking was comparable with, or even more potent than, atrial natriuretic peptide (ANP), an established antidipsogenic hormone, when administered icv, although the antidipsogenic effect lasted longer. ANP had no effect on food intake. Urine volume decreased dose relatedly after icv injection of ghrelin but not by ANP. Intravenous injection of ghrelin had no effect on urine volume. Because drinking usually occurs with feeding, food was withdrawn to remove the prandial drinking. Then the antidipsogenic effect of ghrelin became more potent than that of ANP and continued longer than when food was available. Expression of Fos was increased in the area postrema and the nucleus of the tractus solitarius by using immunohistochemistry after icv and iv injection of ghrelin. The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2006-0993</identifier><identifier>PMID: 17255209</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Animals ; Area postrema ; Atrial natriuretic peptide ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Dietary restrictions ; Dose-Response Relationship, Drug ; Drinking ; Drinking - drug effects ; Eating - drug effects ; Food ; Food availability ; Food intake ; Fundamental and applied biological sciences. Psychology ; Ghrelin ; Immunohistochemistry ; Injection ; Injections, Intravenous ; Injections, Intraventricular ; Male ; Peptide Hormones - administration & dosage ; Peptides ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Wistar ; Time Factors ; Urine ; Vertebrates: endocrinology ; Water deprivation ; Water intake ; Water intakes</subject><ispartof>Endocrinology (Philadelphia), 2007-04, Vol.148 (4), p.1638-1647</ispartof><rights>Copyright © 2007 by the Endocrine Society 2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright © 2007 by the Endocrine Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-549c30bef375be781dfe4e0f771018f308362ee1fafd0f9d515514ad87c707d23</citedby><cites>FETCH-LOGICAL-c520t-549c30bef375be781dfe4e0f771018f308362ee1fafd0f9d515514ad87c707d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18652563$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17255209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashimoto, Hirofumi</creatorcontrib><creatorcontrib>Fujihara, Hiroaki</creatorcontrib><creatorcontrib>Kawasaki, Makoto</creatorcontrib><creatorcontrib>Saito, Takeshi</creatorcontrib><creatorcontrib>Shibata, Minori</creatorcontrib><creatorcontrib>Otsubo, Hiroki</creatorcontrib><creatorcontrib>Takei, Yoshio</creatorcontrib><creatorcontrib>Ueta, Yoichi</creatorcontrib><title>Centrally and Peripherally Administered Ghrelin Potently Inhibits Water Intake in Rats</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after water deprivation was significantly inhibited by icv injection of ghrelin (0.1, 1, and 10 nmol/rat) in a dose-related manner, although food intake was stimulated by the hormone. The antidipsogenic effect was as potent as the orexigenic effect. Similarly, water intake was inhibited, whereas food intake was stimulated dose dependently after iv injection of ghrelin (0.1, 1, and 10 nmol/kg). The inhibition of drinking was comparable with, or even more potent than, atrial natriuretic peptide (ANP), an established antidipsogenic hormone, when administered icv, although the antidipsogenic effect lasted longer. ANP had no effect on food intake. Urine volume decreased dose relatedly after icv injection of ghrelin but not by ANP. Intravenous injection of ghrelin had no effect on urine volume. Because drinking usually occurs with feeding, food was withdrawn to remove the prandial drinking. Then the antidipsogenic effect of ghrelin became more potent than that of ANP and continued longer than when food was available. Expression of Fos was increased in the area postrema and the nucleus of the tractus solitarius by using immunohistochemistry after icv and iv injection of ghrelin. The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats.</description><subject>Animals</subject><subject>Area postrema</subject><subject>Atrial natriuretic peptide</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Dietary restrictions</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking</subject><subject>Drinking - drug effects</subject><subject>Eating - drug effects</subject><subject>Food</subject><subject>Food availability</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin</subject><subject>Immunohistochemistry</subject><subject>Injection</subject><subject>Injections, Intravenous</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Peptide Hormones - administration & dosage</subject><subject>Peptides</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Urine</subject><subject>Vertebrates: endocrinology</subject><subject>Water deprivation</subject><subject>Water intake</subject><subject>Water intakes</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utr3DAQAGBRGppt2lvPxVDaXup0JFmWfAxLmwYCCaGPo9BaI1apV3Yk-5B_HxkbFkpLT2KkTzMaDSFvKJxTRuEzhnMGUJfQNPwZ2dCmEqWkEp6TDQDlpWRMnpKXKd3nsKoq_oKcUsmEYNBsyM8thjGarnssTLDFLUY_7HHZuLAHH3waMaItLvcROx-K237MN_LpVdj7nR9T8ctkkcPR_MYiizszplfkxJku4et1PSM_vn75vv1WXt9cXm0vrss2lx9LUTUthx06LsUOpaLWYYXgpKRAleOgeM0QqTPOgmusoELQylglWwnSMn5GPix5h9g_TJhGffCpxa4zAfspaQlMcVWr_0La1PkT6yrDd3_A-36KITehOeUgVEPZrD4tqo19ShGdHqI_mPioKeh5LBqDnsei57Fk_nZNOu0OaI94nUMG71dgUms6F01ofTo6VQsm6jnRx8X10_CvkuVaki8Sg-3b6AMOEVM6dvPXhz4BWI6w3w</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Hashimoto, Hirofumi</creator><creator>Fujihara, Hiroaki</creator><creator>Kawasaki, Makoto</creator><creator>Saito, Takeshi</creator><creator>Shibata, Minori</creator><creator>Otsubo, Hiroki</creator><creator>Takei, Yoshio</creator><creator>Ueta, Yoichi</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Centrally and Peripherally Administered Ghrelin Potently Inhibits Water Intake in Rats</title><author>Hashimoto, Hirofumi ; Fujihara, Hiroaki ; Kawasaki, Makoto ; Saito, Takeshi ; Shibata, Minori ; Otsubo, Hiroki ; Takei, Yoshio ; Ueta, Yoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-549c30bef375be781dfe4e0f771018f308362ee1fafd0f9d515514ad87c707d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Area postrema</topic><topic>Atrial natriuretic peptide</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Dietary restrictions</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking</topic><topic>Drinking - drug effects</topic><topic>Eating - drug effects</topic><topic>Food</topic><topic>Food availability</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin</topic><topic>Immunohistochemistry</topic><topic>Injection</topic><topic>Injections, Intravenous</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Peptide Hormones - administration & dosage</topic><topic>Peptides</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Urine</topic><topic>Vertebrates: endocrinology</topic><topic>Water deprivation</topic><topic>Water intake</topic><topic>Water intakes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashimoto, Hirofumi</creatorcontrib><creatorcontrib>Fujihara, Hiroaki</creatorcontrib><creatorcontrib>Kawasaki, Makoto</creatorcontrib><creatorcontrib>Saito, Takeshi</creatorcontrib><creatorcontrib>Shibata, Minori</creatorcontrib><creatorcontrib>Otsubo, Hiroki</creatorcontrib><creatorcontrib>Takei, Yoshio</creatorcontrib><creatorcontrib>Ueta, Yoichi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashimoto, Hirofumi</au><au>Fujihara, Hiroaki</au><au>Kawasaki, Makoto</au><au>Saito, Takeshi</au><au>Shibata, Minori</au><au>Otsubo, Hiroki</au><au>Takei, Yoshio</au><au>Ueta, Yoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Centrally and Peripherally Administered Ghrelin Potently Inhibits Water Intake in Rats</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>148</volume><issue>4</issue><spage>1638</spage><epage>1647</epage><pages>1638-1647</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after water deprivation was significantly inhibited by icv injection of ghrelin (0.1, 1, and 10 nmol/rat) in a dose-related manner, although food intake was stimulated by the hormone. The antidipsogenic effect was as potent as the orexigenic effect. Similarly, water intake was inhibited, whereas food intake was stimulated dose dependently after iv injection of ghrelin (0.1, 1, and 10 nmol/kg). The inhibition of drinking was comparable with, or even more potent than, atrial natriuretic peptide (ANP), an established antidipsogenic hormone, when administered icv, although the antidipsogenic effect lasted longer. ANP had no effect on food intake. Urine volume decreased dose relatedly after icv injection of ghrelin but not by ANP. Intravenous injection of ghrelin had no effect on urine volume. Because drinking usually occurs with feeding, food was withdrawn to remove the prandial drinking. Then the antidipsogenic effect of ghrelin became more potent than that of ANP and continued longer than when food was available. Expression of Fos was increased in the area postrema and the nucleus of the tractus solitarius by using immunohistochemistry after icv and iv injection of ghrelin. The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>17255209</pmid><doi>10.1210/en.2006-0993</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-7227 |
| ispartof | Endocrinology (Philadelphia), 2007-04, Vol.148 (4), p.1638-1647 |
| issn | 0013-7227 1945-7170 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70283868 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Area postrema Atrial natriuretic peptide Biological and medical sciences Brain - drug effects Brain - metabolism Dietary restrictions Dose-Response Relationship, Drug Drinking Drinking - drug effects Eating - drug effects Food Food availability Food intake Fundamental and applied biological sciences. Psychology Ghrelin Immunohistochemistry Injection Injections, Intravenous Injections, Intraventricular Male Peptide Hormones - administration & dosage Peptides Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Time Factors Urine Vertebrates: endocrinology Water deprivation Water intake Water intakes |
| title | Centrally and Peripherally Administered Ghrelin Potently Inhibits Water Intake in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T03%3A43%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Centrally%20and%20Peripherally%20Administered%20Ghrelin%20Potently%20Inhibits%20Water%20Intake%20in%20Rats&rft.jtitle=Endocrinology%20(Philadelphia)&rft.au=Hashimoto,%20Hirofumi&rft.date=2007-04-01&rft.volume=148&rft.issue=4&rft.spage=1638&rft.epage=1647&rft.pages=1638-1647&rft.issn=0013-7227&rft.eissn=1945-7170&rft.coden=ENDOAO&rft_id=info:doi/10.1210/en.2006-0993&rft_dat=%3Cproquest_cross%3E70283868%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3130589124&rft_id=info:pmid/17255209&rft_oup_id=10.1210/en.2006-0993&rfr_iscdi=true |