Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause
Background: A high proportion of glandular and stromal tissue in the breast (percentage breast density) is a strong risk factor for breast cancer development. Insulin-like growth factor-I (IGF-I) is hypothesized to influence breast cancer risk by increasing breast density. Objectives: We studied the...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-03, Vol.16 (3), p.451-457 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | VERHEUS, Martijn PEETERS, Petra H. M KAAKS, Rudolf VAN NOORD, Paulus A. H GROBBEE, Diederick E VAN GILS, Carla H |
| description | Background: A high proportion of glandular and stromal tissue in the breast (percentage breast density) is a strong risk factor
for breast cancer development. Insulin-like growth factor-I (IGF-I) is hypothesized to influence breast cancer risk by increasing
breast density.
Objectives: We studied the relation between premenopausal circulating IGF-I levels and premenopausal and postmenopausal, absolute
nondense and dense area, and percentage breast density as well as changes in these measures over menopause.
Design and Methods: Mammograms and blood samples of 684 premenopausal participants of the Prospect-European Prospective Investigation
into Cancer and Nutrition cohort were collected at baseline. A second mammogram of these women was collected after they became
postmenopausal. Premenopausal IGF-I levels were measured in serum. Premenopausal and postmenopausal breast measures were assessed
using a computer-assisted method. Mean values of breast measures were calculated for quartiles of serum IGF-I using linear
regression analysis.
Results: Women with higher premenopausal IGF-I levels showed a slightly smaller decrease in dense area over menopause (−12.2
cm 2 in the highest versus −12.9 cm 2 in the lowest quartile; P trend = 0.58) and, at the same time, a smaller increase in the nondense (fat) area ( P trend = 0.09). Due to the changes over menopause, high premenopausal IGF-I serum levels were associated with lower nondense
area ( P trend = 0.05), somewhat higher dense area ( P trend = 0.66), and consequently higher percentage breast density ( P trend = 0.02) after menopause.
Conclusion and Discussion: Women with higher premenopausal IGF-I levels have a smaller increase in nondense area and also
a slightly smaller decrease in absolute dense area during menopause, resulting in higher breast density after menopause. (Cancer
Epidemiol Biomarkers Prev 2007;16(3):451–7) |
| doi_str_mv | 10.1158/1055-9965.EPI-06-0642 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70281275</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70281275</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-d7315847ac623a9fc1f426d2cfff363522ed52b0c8fe408c4574fed5e61fa0313</originalsourceid><addsrcrecordid>eNqF0U1P3DAQBmALtQJK-QkgX9qeQv3t5Fi2QFfaqkhtz5ZxxsQ0cRY7AfHv69Wm4ljJki3rmbE8L0JnlFxQKuvPlEhZNY2SF1e364qosgQ7QMdU8rrSWso35fzPHKF3OT8QQnQj5SE6opprxgQ5Ru1tggHiuLVztj1exzz3IVab8AfwTRqfpw5fWzeNqVrjn5DmAW_gCfqMbWzxqrPxHjIOEV8msHnCXyHmML3g8QkS_r70hfforbd9htNlP0G_r69-rb5Vmx8369WXTeWE0FPVal5-JrR1inHbeEe9YKplznvPFZeMQSvZHXG1B0FqJ6QWvlyBot4STvkJ-rjvu03j4wx5MkPIDvreRhjnbDRhNWVa_hfSRhFBGl2g3EOXxpwTeLNNYbDpxVBidjmY3YzNbsam5GCIMrscSt358sB8N0D7WrUMvoAPC7DZ2d4nG13Ir67WJS3VFPdp77pw3z2HBMYVCSlBBptcZ6gy3AhJ-V-QMp53</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19604097</pqid></control><display><type>article</type><title>Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>VERHEUS, Martijn ; PEETERS, Petra H. M ; KAAKS, Rudolf ; VAN NOORD, Paulus A. H ; GROBBEE, Diederick E ; VAN GILS, Carla H</creator><creatorcontrib>VERHEUS, Martijn ; PEETERS, Petra H. M ; KAAKS, Rudolf ; VAN NOORD, Paulus A. H ; GROBBEE, Diederick E ; VAN GILS, Carla H</creatorcontrib><description>Background: A high proportion of glandular and stromal tissue in the breast (percentage breast density) is a strong risk factor
for breast cancer development. Insulin-like growth factor-I (IGF-I) is hypothesized to influence breast cancer risk by increasing
breast density.
Objectives: We studied the relation between premenopausal circulating IGF-I levels and premenopausal and postmenopausal, absolute
nondense and dense area, and percentage breast density as well as changes in these measures over menopause.
Design and Methods: Mammograms and blood samples of 684 premenopausal participants of the Prospect-European Prospective Investigation
into Cancer and Nutrition cohort were collected at baseline. A second mammogram of these women was collected after they became
postmenopausal. Premenopausal IGF-I levels were measured in serum. Premenopausal and postmenopausal breast measures were assessed
using a computer-assisted method. Mean values of breast measures were calculated for quartiles of serum IGF-I using linear
regression analysis.
Results: Women with higher premenopausal IGF-I levels showed a slightly smaller decrease in dense area over menopause (−12.2
cm 2 in the highest versus −12.9 cm 2 in the lowest quartile; P trend = 0.58) and, at the same time, a smaller increase in the nondense (fat) area ( P trend = 0.09). Due to the changes over menopause, high premenopausal IGF-I serum levels were associated with lower nondense
area ( P trend = 0.05), somewhat higher dense area ( P trend = 0.66), and consequently higher percentage breast density ( P trend = 0.02) after menopause.
Conclusion and Discussion: Women with higher premenopausal IGF-I levels have a smaller increase in nondense area and also
a slightly smaller decrease in absolute dense area during menopause, resulting in higher breast density after menopause. (Cancer
Epidemiol Biomarkers Prev 2007;16(3):451–7)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-06-0642</identifier><identifier>PMID: 17372240</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; Breast - physiology ; Breast Neoplasms - blood ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Insulin-Like Growth Factor Binding Protein 1 - blood ; Linear Models ; longitudinal study ; Mammary gland diseases ; mammographic density ; Mammography ; Medical sciences ; menopausal changes ; Menopause - blood ; Middle Aged ; Premenopause - blood ; Prospective Studies ; serum IGF-I ; Surveys and Questionnaires ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2007-03, Vol.16 (3), p.451-457</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-d7315847ac623a9fc1f426d2cfff363522ed52b0c8fe408c4574fed5e61fa0313</citedby><cites>FETCH-LOGICAL-c447t-d7315847ac623a9fc1f426d2cfff363522ed52b0c8fe408c4574fed5e61fa0313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18700069$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17372240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VERHEUS, Martijn</creatorcontrib><creatorcontrib>PEETERS, Petra H. M</creatorcontrib><creatorcontrib>KAAKS, Rudolf</creatorcontrib><creatorcontrib>VAN NOORD, Paulus A. H</creatorcontrib><creatorcontrib>GROBBEE, Diederick E</creatorcontrib><creatorcontrib>VAN GILS, Carla H</creatorcontrib><title>Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: A high proportion of glandular and stromal tissue in the breast (percentage breast density) is a strong risk factor
for breast cancer development. Insulin-like growth factor-I (IGF-I) is hypothesized to influence breast cancer risk by increasing
breast density.
Objectives: We studied the relation between premenopausal circulating IGF-I levels and premenopausal and postmenopausal, absolute
nondense and dense area, and percentage breast density as well as changes in these measures over menopause.
Design and Methods: Mammograms and blood samples of 684 premenopausal participants of the Prospect-European Prospective Investigation
into Cancer and Nutrition cohort were collected at baseline. A second mammogram of these women was collected after they became
postmenopausal. Premenopausal IGF-I levels were measured in serum. Premenopausal and postmenopausal breast measures were assessed
using a computer-assisted method. Mean values of breast measures were calculated for quartiles of serum IGF-I using linear
regression analysis.
Results: Women with higher premenopausal IGF-I levels showed a slightly smaller decrease in dense area over menopause (−12.2
cm 2 in the highest versus −12.9 cm 2 in the lowest quartile; P trend = 0.58) and, at the same time, a smaller increase in the nondense (fat) area ( P trend = 0.09). Due to the changes over menopause, high premenopausal IGF-I serum levels were associated with lower nondense
area ( P trend = 0.05), somewhat higher dense area ( P trend = 0.66), and consequently higher percentage breast density ( P trend = 0.02) after menopause.
Conclusion and Discussion: Women with higher premenopausal IGF-I levels have a smaller increase in nondense area and also
a slightly smaller decrease in absolute dense area during menopause, resulting in higher breast density after menopause. (Cancer
Epidemiol Biomarkers Prev 2007;16(3):451–7)</description><subject>Biological and medical sciences</subject><subject>Breast - physiology</subject><subject>Breast Neoplasms - blood</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - blood</subject><subject>Linear Models</subject><subject>longitudinal study</subject><subject>Mammary gland diseases</subject><subject>mammographic density</subject><subject>Mammography</subject><subject>Medical sciences</subject><subject>menopausal changes</subject><subject>Menopause - blood</subject><subject>Middle Aged</subject><subject>Premenopause - blood</subject><subject>Prospective Studies</subject><subject>serum IGF-I</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1P3DAQBmALtQJK-QkgX9qeQv3t5Fi2QFfaqkhtz5ZxxsQ0cRY7AfHv69Wm4ljJki3rmbE8L0JnlFxQKuvPlEhZNY2SF1e364qosgQ7QMdU8rrSWso35fzPHKF3OT8QQnQj5SE6opprxgQ5Ru1tggHiuLVztj1exzz3IVab8AfwTRqfpw5fWzeNqVrjn5DmAW_gCfqMbWzxqrPxHjIOEV8msHnCXyHmML3g8QkS_r70hfforbd9htNlP0G_r69-rb5Vmx8369WXTeWE0FPVal5-JrR1inHbeEe9YKplznvPFZeMQSvZHXG1B0FqJ6QWvlyBot4STvkJ-rjvu03j4wx5MkPIDvreRhjnbDRhNWVa_hfSRhFBGl2g3EOXxpwTeLNNYbDpxVBidjmY3YzNbsam5GCIMrscSt358sB8N0D7WrUMvoAPC7DZ2d4nG13Ir67WJS3VFPdp77pw3z2HBMYVCSlBBptcZ6gy3AhJ-V-QMp53</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>VERHEUS, Martijn</creator><creator>PEETERS, Petra H. M</creator><creator>KAAKS, Rudolf</creator><creator>VAN NOORD, Paulus A. H</creator><creator>GROBBEE, Diederick E</creator><creator>VAN GILS, Carla H</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause</title><author>VERHEUS, Martijn ; PEETERS, Petra H. M ; KAAKS, Rudolf ; VAN NOORD, Paulus A. H ; GROBBEE, Diederick E ; VAN GILS, Carla H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-d7315847ac623a9fc1f426d2cfff363522ed52b0c8fe408c4574fed5e61fa0313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Biological and medical sciences</topic><topic>Breast - physiology</topic><topic>Breast Neoplasms - blood</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - blood</topic><topic>Linear Models</topic><topic>longitudinal study</topic><topic>Mammary gland diseases</topic><topic>mammographic density</topic><topic>Mammography</topic><topic>Medical sciences</topic><topic>menopausal changes</topic><topic>Menopause - blood</topic><topic>Middle Aged</topic><topic>Premenopause - blood</topic><topic>Prospective Studies</topic><topic>serum IGF-I</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VERHEUS, Martijn</creatorcontrib><creatorcontrib>PEETERS, Petra H. M</creatorcontrib><creatorcontrib>KAAKS, Rudolf</creatorcontrib><creatorcontrib>VAN NOORD, Paulus A. H</creatorcontrib><creatorcontrib>GROBBEE, Diederick E</creatorcontrib><creatorcontrib>VAN GILS, Carla H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VERHEUS, Martijn</au><au>PEETERS, Petra H. M</au><au>KAAKS, Rudolf</au><au>VAN NOORD, Paulus A. H</au><au>GROBBEE, Diederick E</au><au>VAN GILS, Carla H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>16</volume><issue>3</issue><spage>451</spage><epage>457</epage><pages>451-457</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Background: A high proportion of glandular and stromal tissue in the breast (percentage breast density) is a strong risk factor
for breast cancer development. Insulin-like growth factor-I (IGF-I) is hypothesized to influence breast cancer risk by increasing
breast density.
Objectives: We studied the relation between premenopausal circulating IGF-I levels and premenopausal and postmenopausal, absolute
nondense and dense area, and percentage breast density as well as changes in these measures over menopause.
Design and Methods: Mammograms and blood samples of 684 premenopausal participants of the Prospect-European Prospective Investigation
into Cancer and Nutrition cohort were collected at baseline. A second mammogram of these women was collected after they became
postmenopausal. Premenopausal IGF-I levels were measured in serum. Premenopausal and postmenopausal breast measures were assessed
using a computer-assisted method. Mean values of breast measures were calculated for quartiles of serum IGF-I using linear
regression analysis.
Results: Women with higher premenopausal IGF-I levels showed a slightly smaller decrease in dense area over menopause (−12.2
cm 2 in the highest versus −12.9 cm 2 in the lowest quartile; P trend = 0.58) and, at the same time, a smaller increase in the nondense (fat) area ( P trend = 0.09). Due to the changes over menopause, high premenopausal IGF-I serum levels were associated with lower nondense
area ( P trend = 0.05), somewhat higher dense area ( P trend = 0.66), and consequently higher percentage breast density ( P trend = 0.02) after menopause.
Conclusion and Discussion: Women with higher premenopausal IGF-I levels have a smaller increase in nondense area and also
a slightly smaller decrease in absolute dense area during menopause, resulting in higher breast density after menopause. (Cancer
Epidemiol Biomarkers Prev 2007;16(3):451–7)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17372240</pmid><doi>10.1158/1055-9965.EPI-06-0642</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2007-03, Vol.16 (3), p.451-457 |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Breast - physiology Breast Neoplasms - blood Female Gynecology. Andrology. Obstetrics Humans Insulin-Like Growth Factor Binding Protein 1 - blood Linear Models longitudinal study Mammary gland diseases mammographic density Mammography Medical sciences menopausal changes Menopause - blood Middle Aged Premenopause - blood Prospective Studies serum IGF-I Surveys and Questionnaires Tumors |
| title | Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause |
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