Anti-malarial drug targets: Screening for inhibitors of 2C-methyl- d-erythritol 4-phosphate synthase (IspC protein) in Mediterranean plants

The recently discovered non-mevalonate pathway of isoprenoid biosynthesis serves as the unique source of terpenoids in numerous pathogenic eubacteria and in apicoplast-type protozoa, most notably Plasmodium, but is absent in mammalian cells. It is therefore an attractive target for anti-infective ch...

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