The Non-structural Protein 4A of Dengue Virus Is an Integral Membrane Protein Inducing Membrane Alterations in a 2K-regulated Manner

Dengue virus (DV) is a positive sense RNA virus replicating in the cytoplasm in membranous compartments that are induced by viral infection. The non-structural protein (NS) 4A is one of the least characterized DV proteins. It is highly hydrophobic with its C-terminal region (designated 2K fragment)...

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Veröffentlicht in:	The Journal of biological chemistry 2007-03, Vol.282 (12), p.8873-8882
Hauptverfasser:	Miller, Sven, Kastner, Stefan, Krijnse-Locker, Jacomine, Bühler, Sandra, Bartenschlager, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Membrane - metabolism Cytoplasm - metabolism Dengue virus Dengue Virus - metabolism Endoplasmic Reticulum - metabolism Gene Expression Regulation, Viral Glycosylation Humans Microscopy, Confocal Models, Biological Models, Genetic Protein Structure, Tertiary RNA - chemistry RNA, Viral - chemistry Viral Nonstructural Proteins - biosynthesis Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism Viral Nonstructural Proteins - physiology
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