Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells

It has been suggested that PI3K participates in TLR signaling. However, identifying specific roles for individual PI3K subtypes in signaling has remained elusive. In macrophages from the p110gamma(-/-) mouse, LPS-induced phosphorylation of Akt occurred normally despite the fact that the action of an...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-02, Vol.180 (4), p.2054-2061
Hauptverfasser:	Tsukamoto, Ken, Hazeki, Kaoru, Hoshi, Megumi, Nigorikawa, Kiyomi, Inoue, Norimitsu, Sasaki, Takehiko, Hazeki, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Class I Phosphatidylinositol 3-Kinases Down-Regulation - genetics Down-Regulation - immunology Enzyme Activation - genetics Enzyme Activation - immunology Female Gene Expression Regulation - immunology Isoenzymes - deficiency Isoenzymes - genetics Isoenzymes - physiology Lipopolysaccharides - pharmacology Macrophages - immunology Macrophages - metabolism Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mice Mice, Inbred C57BL Mice, Knockout Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics Nitrites - antagonists & inhibitors Nitrites - metabolism Phosphatidylinositol 3-Kinases - deficiency Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - physiology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - immunology Toll-Like Receptors - physiology
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