Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human gamma delta T cell activator

(E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) is an intermediate in the non-mevalonate pathway for the biosynthesis of isoprenoids and also serves as a very strong activator of human gamma delta T cells expressing Vgamma9Vdelta2 receptors. This paper describes the synthesis of analogues of...

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Veröffentlicht in:	Journal of organic chemistry 2008-02, Vol.73 (4), p.1365-1370
Hauptverfasser:	Van Hoof, Steven, Lacey, Carl Jeffrey, Röhrich, René C, Wiesner, Jochen, Jomaa, Hassan, Van Calenbergh, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Magnetic Resonance Spectroscopy Phosphates - chemical synthesis Phosphates - pharmacology Receptors, Antigen, T-Cell, gamma-delta - agonists Spectrometry, Mass, Electrospray Ionization
Online-Zugang:	Volltext
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