Blockade of p38 mitogen-activated protein kinase pathway ameliorates delayed intestinal transit in burned rats

Abstract Background Burn injury has been shown to impair intestinal transit. p38 mitogen-activated protein kinase (MAPK) has been shown to be involved in the production of proinflammatory mediators such as interleukin (IL)-1β, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). The...

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Veröffentlicht in:	The American journal of surgery 2007-04, Vol.193 (4), p.530-537
Hauptverfasser:	Gan, Hua Tian, M.D., Ph.D, Pasricha, Pankaj J., M.D, Chen, Jiande D.Z., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Burn Burns Burns - complications Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase-2 (COX-2) Disease Models, Animal Enzyme Inhibitors - pharmacology Gastrointestinal Transit - drug effects General aspects Imidazoles - pharmacology Intestinal Diseases - etiology Intestinal Diseases - physiopathology Intestinal transit Kinases Male Medical sciences Mortality Nitric oxide synthase (iNOS) p38 MAPK p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Pyridines - pharmacology Rats Rats, Sprague-Dawley Rodents Studies Sulfonamides - pharmacology Surgery Thiourea - pharmacology Traumas. Diseases due to physical agents
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