Inflammation and Breakdown of the Blood-Retinal Barrier During "Physiological Aging" in the Rat Retina: A Model for CNS Aging

Objective: To examine the possible contribution of inflammation and breakdown of the blood-brain barrier in the central nervous system (CNS) of physiologically aged rats showing cognitive decline. Methods: Young (3- to 6-month-old) and aged (24- to 30-month-old) Wistar rats were assessed by the nove...

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Veröffentlicht in:	Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2007, Vol.14 (1), p.63-76
Hauptverfasser:	Chan-Ling, Tailoi, Hughes, Suzanne, Baxter, Louise, Rosinova, Emelia, McGregor, Iain, Morcos, Yvette, van Nieuwenhuyzen, Petra, Hu, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - immunology Aging - pathology Animals Antibodies antigen presentation blood-brain barrier Blood-Brain Barrier - immunology Blood-Brain Barrier - pathology blood-retinal barrier Cognition Disorders - immunology Cognition Disorders - pathology Disease Models, Animal Ectodysplasins - metabolism Female Histocompatibility Antigens Class II - metabolism Horseradish Peroxidase Indicators and Reagents Indoles inflammation Inflammation - immunology Inflammation - pathology Inflammation - physiopathology Male Membrane Proteins - immunology Microcirculation - immunology microglia Microglia - immunology Microglia - metabolism Microglia - pathology Monocytes - immunology Monocytes - metabolism Monocytes - pathology neurodegeneration Occludin Organometallic Compounds Protein Transport - immunology Rats Rats, Wistar retina Retinal Vessels - immunology Retinal Vessels - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology Tight Junctions - physiology
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