Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort : The role of FGB -455 G/A polymorphism
Given the hypothesis of a common soil for atherosclerosis, type 2 diabetes and metabolic syndrome, we tested the contribution of gene polymorphisms involved in cardiovascular diseases on fasting insulin concentration (FIC). The polymorphisms were investigated by a multiplex assay in 308 apparently h...
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| Veröffentlicht in: | Atherosclerosis 2007-04, Vol.191 (2), p.369-376 |
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| creator | MAUMUS, Sandy MARIE, Bérangère VINCENT-VIRY, Monique SIEST, Gérard VISVIKIS-SIEST, Sophie |
| description | Given the hypothesis of a common soil for atherosclerosis, type 2 diabetes and metabolic syndrome, we tested the contribution of gene polymorphisms involved in cardiovascular diseases on fasting insulin concentration (FIC).
The polymorphisms were investigated by a multiplex assay in 308 apparently healthy French middle-aged men and women, taken from the STANISLAS cohort. FIC was measured by a microparticular enzymatic immunoassay.
After a series of regression analyses involving 34 polymorphisms, FGB -455G/A was the only polymorphism that remained significantly associated with FIC when adjusting the analyses for multiple testing. Stepwise models showed that FGB polymorphism accounted for 4.39% of FIC variability in men. Additionally, interactions between FGB and with environmental factors (alcohol and smoking in men, and BMI in women) were found.
To our knowledge, this is the first study reporting an influence of FGB polymorphism on FIC in a healthy population. Our results concord with the already shown link between fibrinogen concentration and FIC, and support the hypothesis of a relationship between fibrinogen and endothelium in FIC homeostasis whose alteration may induce several metabolic disorders. The contribution of this gene, although modest, is consistent with the polygenic nature of insulin levels. |
| doi_str_mv | 10.1016/j.atherosclerosis.2006.04.003 |
| format | Article |
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The polymorphisms were investigated by a multiplex assay in 308 apparently healthy French middle-aged men and women, taken from the STANISLAS cohort. FIC was measured by a microparticular enzymatic immunoassay.
After a series of regression analyses involving 34 polymorphisms, FGB -455G/A was the only polymorphism that remained significantly associated with FIC when adjusting the analyses for multiple testing. Stepwise models showed that FGB polymorphism accounted for 4.39% of FIC variability in men. Additionally, interactions between FGB and with environmental factors (alcohol and smoking in men, and BMI in women) were found.
To our knowledge, this is the first study reporting an influence of FGB polymorphism on FIC in a healthy population. Our results concord with the already shown link between fibrinogen concentration and FIC, and support the hypothesis of a relationship between fibrinogen and endothelium in FIC homeostasis whose alteration may induce several metabolic disorders. The contribution of this gene, although modest, is consistent with the polygenic nature of insulin levels.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2006.04.003</identifier><identifier>PMID: 16697386</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Adenine ; Adult ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - genetics ; Cohort Studies ; Coronary heart disease ; Cross-Sectional Studies ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Fasting - blood ; Female ; Fibrinogen - genetics ; France ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Guanine ; Heart ; Homeostasis - genetics ; Humans ; Immunoenzyme Techniques - methods ; Insulin - blood ; Male ; Medical sciences ; Metabolic Syndrome - blood ; Metabolic Syndrome - complications ; Metabolic Syndrome - genetics ; Middle Aged ; Polymorphism, Single Nucleotide ; Reference Values ; Risk Factors</subject><ispartof>Atherosclerosis, 2007-04, Vol.191 (2), p.369-376</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18633904$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16697386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MAUMUS, Sandy</creatorcontrib><creatorcontrib>MARIE, Bérangère</creatorcontrib><creatorcontrib>VINCENT-VIRY, Monique</creatorcontrib><creatorcontrib>SIEST, Gérard</creatorcontrib><creatorcontrib>VISVIKIS-SIEST, Sophie</creatorcontrib><title>Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort : The role of FGB -455 G/A polymorphism</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Given the hypothesis of a common soil for atherosclerosis, type 2 diabetes and metabolic syndrome, we tested the contribution of gene polymorphisms involved in cardiovascular diseases on fasting insulin concentration (FIC).
The polymorphisms were investigated by a multiplex assay in 308 apparently healthy French middle-aged men and women, taken from the STANISLAS cohort. FIC was measured by a microparticular enzymatic immunoassay.
After a series of regression analyses involving 34 polymorphisms, FGB -455G/A was the only polymorphism that remained significantly associated with FIC when adjusting the analyses for multiple testing. Stepwise models showed that FGB polymorphism accounted for 4.39% of FIC variability in men. Additionally, interactions between FGB and with environmental factors (alcohol and smoking in men, and BMI in women) were found.
To our knowledge, this is the first study reporting an influence of FGB polymorphism on FIC in a healthy population. Our results concord with the already shown link between fibrinogen concentration and FIC, and support the hypothesis of a relationship between fibrinogen and endothelium in FIC homeostasis whose alteration may induce several metabolic disorders. The contribution of this gene, although modest, is consistent with the polygenic nature of insulin levels.</description><subject>Adenine</subject><subject>Adult</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cohort Studies</subject><subject>Coronary heart disease</subject><subject>Cross-Sectional Studies</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Fibrinogen - genetics</subject><subject>France</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Guanine</subject><subject>Heart</subject><subject>Homeostasis - genetics</subject><subject>Humans</subject><subject>Immunoenzyme Techniques - methods</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Syndrome - blood</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - genetics</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Reference Values</subject><subject>Risk Factors</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFu1DAQhiMEokvhFZAv5ZbUThwn4Raqdqm0gsMu59WsMyYujh1sp1IekbfCLQtcZjS_vvnn12TZFaMFo0xcPxQQR_QuSPNUdShKSkVBeUFp9SLbsLbpcsZb_jLbUFqyvGM1vcjehPBAKeUNa19nF0yIrqlascl-9RbMmmyIUyQZE1QKZXyapsVEPRsk39Fi1JI8gtdg4zMqwQ_aPUKQiwFPBh0QAhKvww_iLNE2LEZbIp2VaKOHqJP6bHDSRsc1EWREMHFcCQzp0r8A-0P_5X6_6_dpeXQ-ko_kkGTvUpKE3G0_kZzXNdle92R2Zp2cn0cdprfZKwUm4Ltzv8y-3d0ebj7nu6_b-5t-l89l1cVcyPakJBesAtWxFttGSYFsaETJacdrjqVEobo6yUAb1Qx0UC1UWJZDfRqgusw-_PGdvfu5YIjHSQeJxoBFt4RjQ8tGVIIn8P0ZXE4TDsfZ6wn8evz7_ARcnYH0RjDKg5U6_OcSUnWUV78B6z2cvA</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>MAUMUS, Sandy</creator><creator>MARIE, Bérangère</creator><creator>VINCENT-VIRY, Monique</creator><creator>SIEST, Gérard</creator><creator>VISVIKIS-SIEST, Sophie</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort : The role of FGB -455 G/A polymorphism</title><author>MAUMUS, Sandy ; MARIE, Bérangère ; VINCENT-VIRY, Monique ; SIEST, Gérard ; VISVIKIS-SIEST, Sophie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-6c8bfc4613af918e87fc6e1d762409454e2ce6f95fc6a07f7d0df8a3e22d5bda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenine</topic><topic>Adult</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Cohort Studies</topic><topic>Coronary heart disease</topic><topic>Cross-Sectional Studies</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Fibrinogen - genetics</topic><topic>France</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Guanine</topic><topic>Heart</topic><topic>Homeostasis - genetics</topic><topic>Humans</topic><topic>Immunoenzyme Techniques - methods</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Syndrome - blood</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - genetics</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Reference Values</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAUMUS, Sandy</creatorcontrib><creatorcontrib>MARIE, Bérangère</creatorcontrib><creatorcontrib>VINCENT-VIRY, Monique</creatorcontrib><creatorcontrib>SIEST, Gérard</creatorcontrib><creatorcontrib>VISVIKIS-SIEST, Sophie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAUMUS, Sandy</au><au>MARIE, Bérangère</au><au>VINCENT-VIRY, Monique</au><au>SIEST, Gérard</au><au>VISVIKIS-SIEST, Sophie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort : The role of FGB -455 G/A polymorphism</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>191</volume><issue>2</issue><spage>369</spage><epage>376</epage><pages>369-376</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Given the hypothesis of a common soil for atherosclerosis, type 2 diabetes and metabolic syndrome, we tested the contribution of gene polymorphisms involved in cardiovascular diseases on fasting insulin concentration (FIC).
The polymorphisms were investigated by a multiplex assay in 308 apparently healthy French middle-aged men and women, taken from the STANISLAS cohort. FIC was measured by a microparticular enzymatic immunoassay.
After a series of regression analyses involving 34 polymorphisms, FGB -455G/A was the only polymorphism that remained significantly associated with FIC when adjusting the analyses for multiple testing. Stepwise models showed that FGB polymorphism accounted for 4.39% of FIC variability in men. Additionally, interactions between FGB and with environmental factors (alcohol and smoking in men, and BMI in women) were found.
To our knowledge, this is the first study reporting an influence of FGB polymorphism on FIC in a healthy population. Our results concord with the already shown link between fibrinogen concentration and FIC, and support the hypothesis of a relationship between fibrinogen and endothelium in FIC homeostasis whose alteration may induce several metabolic disorders. The contribution of this gene, although modest, is consistent with the polygenic nature of insulin levels.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>16697386</pmid><doi>10.1016/j.atherosclerosis.2006.04.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Adenine Adult Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Cohort Studies Coronary heart disease Cross-Sectional Studies Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fasting - blood Female Fibrinogen - genetics France Gene Frequency Genetic Predisposition to Disease Genotype Guanine Heart Homeostasis - genetics Humans Immunoenzyme Techniques - methods Insulin - blood Male Medical sciences Metabolic Syndrome - blood Metabolic Syndrome - complications Metabolic Syndrome - genetics Middle Aged Polymorphism, Single Nucleotide Reference Values Risk Factors |
| title | Analysis of the effect of multiple genetic variants of cardiovascular disease risk on insulin concentration variability in healthy adults of the STANISLAS cohort : The role of FGB -455 G/A polymorphism |
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