G-rich proto-oncogenes are targeted for genomic instability in B-cell lymphomas

Diffuse large B-cell lymphoma is the most common lymphoid malignancy in adults. It is a heterogeneous disease with variability in outcome. Genomic instability of a subset of proto-oncogenes, including c-MYC, BCL6, RhoH, PIM1, and PAX5, can contribute to initial tumor development and has been correla...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-03, Vol.67 (6), p.2586-2594
Hauptverfasser:	DUQUETTE, Michelle L, HUBER, Michael D, MAIZELS, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents B-Lymphocytes - enzymology B-Lymphocytes - pathology Biological and medical sciences Genomic Instability Guanosine - genetics Hematologic and hematopoietic diseases Humans Immunoglobulins - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - enzymology Lymphoma, B-Cell - genetics Medical sciences Nucleic Acid Conformation Nucleoside Deaminases - metabolism Pharmacology. Drug treatments Proto-Oncogenes Transcription, Genetic Tumors
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