Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets

The successful treatment of cancer requires a clear understanding of multiple interacting factors involved in the development of drug resistance. Presently, two hypotheses, genetic and epigenetic, have been proposed to explain mechanisms of acquired cancer drug resistance. In the present study, we e...

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Veröffentlicht in:	Molecular cancer therapeutics 2007-03, Vol.6 (3), p.1089-1098
Hauptverfasser:	Chekhun, Vasyl' F, Lukyanova, Nataliya Yu, Kovalchuk, Olga, Tryndyak, Volodymyr P, Pogribny, Igor P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - metabolism Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cisplatin - pharmacology DNA hypermethylation DNA hypomethylation DNA Methylation - drug effects Doxorubicin - pharmacology drug resistance Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm Epigenesis, Genetic Gene Expression Regulation, Neoplastic - drug effects Histone-Lysine N-Methyltransferase - antagonists & inhibitors Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Histones - metabolism Humans MCF-7 p73 Protein Methyltransferases sulfatase 2 Tumor Cells, Cultured - drug effects
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