One-Pot Synthesis of 3-Fluoro-4-(trifluoromethyl)quinolines from Pentafluoropropen-2-ol and Their Molecular Modification

Pentafluoropropen-2-ol (PFP) was prepared by the reaction of hexafluoroacetone (HFA) with Mg/TMSCl. The one-pot tandem sequential reactions of PFP via Mannich addition with aldimines followed by Friedel−Crafts cyclization and aromatization afforded the title quinolines. A variety of corresponding 3-...

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Veröffentlicht in:	Journal of organic chemistry 2008-02, Vol.73 (4), p.1468-1474
Hauptverfasser:	Hosokawa, Tsuyoshi, Matsumura, Akemi, Katagiri, Toshimasa, Uneyama, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Magnetic Resonance Spectroscopy Organic chemistry Preparations and properties Quinolines - chemical synthesis Quinolines - chemistry Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared
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