Epigallocatechin Gallate's Protective Effect against MMP7 in Recessive Dystrophic Epidermolysis Bullosa Patients
The analysis of phenotype–genotype correlations of patients suffering from recessive dystrophic epidermolysis bullosa (RDEB) evidenced intrafamilial and interfamilial phenotype variability occurring for the same mutation of COL7A1; this underscores the role of other genetics environmental factors in...
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| Veröffentlicht in: | Journal of investigative dermatology 2007-04, Vol.127 (4), p.821-828 |
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| creator | Changotade, Sylvie Igondjo-Tchen Assoumou, Antoine Guéniche, Farida Fioretti, Florence Séguier, Sylvie de Prost, Yves Bodemer, Christine Godeau, Gaston Senni, Karim |
| description | The analysis of phenotype–genotype correlations of patients suffering from recessive dystrophic epidermolysis bullosa (RDEB) evidenced intrafamilial and interfamilial phenotype variability occurring for the same mutation of COL7A1; this underscores the role of other genetics environmental factors in the expressivity of the disease. In this work, we checked whether matrilysin 1 (matrix metalloproteinase (MMP)7) could take part in the epidermal detachment in RDEB. Furthermore, we investigated epigallocatechin 3 gallate (EGCG) to determine whether it could inhibit matrilysin activities on collagen type VII and fibrillin 1 known to be associated with the dermo-epidermal junction. In this work, matrilysin 1 was detected in affected and unaffected skins of the three RDEB patients; furthermore, MMP7 was shown to degrade ex vivo on healthy normal skin collagen VII and fibrillin 1. Thus, we suspect that MMP7 could take an active part in the epidermal detachment occurring during RDEB. We evidenced that EGCG in in vitro as well as in ex vivo experiments was a good inhibitor of MMP7 and developed a good protection of collagen type VII and fibrillin 1 susceptible of being degraded by MMP7. We therefore propose that EGCG could be used beneficially in patients suffering from RDEB. |
| doi_str_mv | 10.1038/sj.jid.5700645 |
| format | Article |
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In this work, we checked whether matrilysin 1 (matrix metalloproteinase (MMP)7) could take part in the epidermal detachment in RDEB. Furthermore, we investigated epigallocatechin 3 gallate (EGCG) to determine whether it could inhibit matrilysin activities on collagen type VII and fibrillin 1 known to be associated with the dermo-epidermal junction. In this work, matrilysin 1 was detected in affected and unaffected skins of the three RDEB patients; furthermore, MMP7 was shown to degrade ex vivo on healthy normal skin collagen VII and fibrillin 1. Thus, we suspect that MMP7 could take an active part in the epidermal detachment occurring during RDEB. We evidenced that EGCG in in vitro as well as in ex vivo experiments was a good inhibitor of MMP7 and developed a good protection of collagen type VII and fibrillin 1 susceptible of being degraded by MMP7. We therefore propose that EGCG could be used beneficially in patients suffering from RDEB.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/sj.jid.5700645</identifier><identifier>PMID: 17139264</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Adult ; Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Biological and medical sciences ; Blotting, Western ; Bullous diseases of the skin ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Collagen Type VII - metabolism ; Dermatology ; Elastic Tissue - pathology ; Epidermolysis Bullosa Dystrophica - genetics ; Epidermolysis Bullosa Dystrophica - pathology ; Epidermolysis Bullosa Dystrophica - physiopathology ; Fibrillin-1 ; Fibrillins ; Genes, Recessive ; Humans ; Immunologic Techniques ; Matrix Metalloproteinase 7 - metabolism ; Matrix Metalloproteinase Inhibitors ; Medical sciences ; Microfilament Proteins - metabolism ; Organ Culture Techniques ; Protease Inhibitors - pharmacology ; Skin - enzymology ; Skin - pathology ; Staining and Labeling ; Time Factors ; Tissue Distribution</subject><ispartof>Journal of investigative dermatology, 2007-04, Vol.127 (4), p.821-828</ispartof><rights>2007 The Society for Investigative Dermatology, Inc</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-57aee1868d31488bacf9610049d163fc966e73ad9d46b35823284c40d92810343</citedby><cites>FETCH-LOGICAL-c527t-57aee1868d31488bacf9610049d163fc966e73ad9d46b35823284c40d92810343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210380292?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19046248$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17139264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Changotade, Sylvie Igondjo-Tchen</creatorcontrib><creatorcontrib>Assoumou, Antoine</creatorcontrib><creatorcontrib>Guéniche, Farida</creatorcontrib><creatorcontrib>Fioretti, Florence</creatorcontrib><creatorcontrib>Séguier, Sylvie</creatorcontrib><creatorcontrib>de Prost, Yves</creatorcontrib><creatorcontrib>Bodemer, Christine</creatorcontrib><creatorcontrib>Godeau, Gaston</creatorcontrib><creatorcontrib>Senni, Karim</creatorcontrib><title>Epigallocatechin Gallate's Protective Effect against MMP7 in Recessive Dystrophic Epidermolysis Bullosa Patients</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>The analysis of phenotype–genotype correlations of patients suffering from recessive dystrophic epidermolysis bullosa (RDEB) evidenced intrafamilial and interfamilial phenotype variability occurring for the same mutation of COL7A1; this underscores the role of other genetics environmental factors in the expressivity of the disease. In this work, we checked whether matrilysin 1 (matrix metalloproteinase (MMP)7) could take part in the epidermal detachment in RDEB. Furthermore, we investigated epigallocatechin 3 gallate (EGCG) to determine whether it could inhibit matrilysin activities on collagen type VII and fibrillin 1 known to be associated with the dermo-epidermal junction. In this work, matrilysin 1 was detected in affected and unaffected skins of the three RDEB patients; furthermore, MMP7 was shown to degrade ex vivo on healthy normal skin collagen VII and fibrillin 1. Thus, we suspect that MMP7 could take an active part in the epidermal detachment occurring during RDEB. We evidenced that EGCG in in vitro as well as in ex vivo experiments was a good inhibitor of MMP7 and developed a good protection of collagen type VII and fibrillin 1 susceptible of being degraded by MMP7. 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Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Changotade, Sylvie Igondjo-Tchen</au><au>Assoumou, Antoine</au><au>Guéniche, Farida</au><au>Fioretti, Florence</au><au>Séguier, Sylvie</au><au>de Prost, Yves</au><au>Bodemer, Christine</au><au>Godeau, Gaston</au><au>Senni, Karim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigallocatechin Gallate's Protective Effect against MMP7 in Recessive Dystrophic Epidermolysis Bullosa Patients</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>127</volume><issue>4</issue><spage>821</spage><epage>828</epage><pages>821-828</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><coden>JIDEAE</coden><abstract>The analysis of phenotype–genotype correlations of patients suffering from recessive dystrophic epidermolysis bullosa (RDEB) evidenced intrafamilial and interfamilial phenotype variability occurring for the same mutation of COL7A1; this underscores the role of other genetics environmental factors in the expressivity of the disease. In this work, we checked whether matrilysin 1 (matrix metalloproteinase (MMP)7) could take part in the epidermal detachment in RDEB. Furthermore, we investigated epigallocatechin 3 gallate (EGCG) to determine whether it could inhibit matrilysin activities on collagen type VII and fibrillin 1 known to be associated with the dermo-epidermal junction. In this work, matrilysin 1 was detected in affected and unaffected skins of the three RDEB patients; furthermore, MMP7 was shown to degrade ex vivo on healthy normal skin collagen VII and fibrillin 1. Thus, we suspect that MMP7 could take an active part in the epidermal detachment occurring during RDEB. We evidenced that EGCG in in vitro as well as in ex vivo experiments was a good inhibitor of MMP7 and developed a good protection of collagen type VII and fibrillin 1 susceptible of being degraded by MMP7. We therefore propose that EGCG could be used beneficially in patients suffering from RDEB.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>17139264</pmid><doi>10.1038/sj.jid.5700645</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Biological and medical sciences Blotting, Western Bullous diseases of the skin Catechin - analogs & derivatives Catechin - pharmacology Collagen Type VII - metabolism Dermatology Elastic Tissue - pathology Epidermolysis Bullosa Dystrophica - genetics Epidermolysis Bullosa Dystrophica - pathology Epidermolysis Bullosa Dystrophica - physiopathology Fibrillin-1 Fibrillins Genes, Recessive Humans Immunologic Techniques Matrix Metalloproteinase 7 - metabolism Matrix Metalloproteinase Inhibitors Medical sciences Microfilament Proteins - metabolism Organ Culture Techniques Protease Inhibitors - pharmacology Skin - enzymology Skin - pathology Staining and Labeling Time Factors Tissue Distribution |
| title | Epigallocatechin Gallate's Protective Effect against MMP7 in Recessive Dystrophic Epidermolysis Bullosa Patients |
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