Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death

Xanthohumol (X), isoxanthohumol (IX), 8‐prenylnaringenin (8PN) and 6‐prenylnaringenin (6PN), prenylflavonoids from hop (Humulus lupulus L.), were investigated for their cytotoxicity and the mechanism by which they exert cell death when incubated with prostate cancer cell lines PC‐3 and DU145. All co...

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Veröffentlicht in:	Phytotherapy research 2008-02, Vol.22 (2), p.197-203
Hauptverfasser:	Delmulle, L., Berghe, T. Vanden, Keukeleire, D. De, Vandenabeele, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Biological and medical sciences Caspase 3 - metabolism Caspase Inhibitors caspases Caspases - metabolism Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Cysteine Proteinase Inhibitors - pharmacology Dose-Response Relationship, Drug Flavanones - chemistry Flavanones - pharmacology Flavonoids - chemistry Flavonoids - pharmacology General pharmacology hop Humans Humulus - chemistry Male Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology prenylflavonoids Propiophenones - chemistry Propiophenones - pharmacology prostate cancer cells Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology Xanthones - chemistry Xanthones - pharmacology
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