Comparison between international normalized ratio using a portable device and conventional methodology
to compare the international normalized ratio (INR) measured by a point-of-care (POC) testing device with that measured by the conventional method in patients undergoing anticoagulation therapy with warfarin sodium. The INR of 383 warfarin-treated patients (mean age: 56.5 years; 207 female) was meas...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 2007-01, Vol.88 (1), p.31-34 |
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| container_title | Arquivos brasileiros de cardiologia |
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| creator | De Piano, Luciana Pereira Almeida Strunz, Célia Maria Cássaro Mansur, Antonio de Pádua Rached, Roberto Abi |
| description | to compare the international normalized ratio (INR) measured by a point-of-care (POC) testing device with that measured by the conventional method in patients undergoing anticoagulation therapy with warfarin sodium.
The INR of 383 warfarin-treated patients (mean age: 56.5 years; 207 female) was measured in capillary blood using the Hemochron Jr. device and compared with that of venous plasma samples determined by the conventional method performed in a Coag-A-Mate analyzer. Results were evaluated globally and for the following subgroups: INR < 2.0, from 2.0 to 3.5, and > 3.5.
Using both methods, the comparison between INR values yielded a correlation coefficient (r) of 0.86. However, mean differences in INR in both tests, considering the three subgroups, proved to be statistically significant (p 3.5). Paired Students t-test analysis revealed a p value < 0.001 for the three subgroups studied.
The use of point-of-care testing for monitoring oral anticoagulation has some limitations. Anticoagulation intensity was underestimated by this method in the three subgroups studied. |
| doi_str_mv | 10.1590/S0066-782X2007000100005 |
| format | Article |
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The INR of 383 warfarin-treated patients (mean age: 56.5 years; 207 female) was measured in capillary blood using the Hemochron Jr. device and compared with that of venous plasma samples determined by the conventional method performed in a Coag-A-Mate analyzer. Results were evaluated globally and for the following subgroups: INR < 2.0, from 2.0 to 3.5, and > 3.5.
Using both methods, the comparison between INR values yielded a correlation coefficient (r) of 0.86. However, mean differences in INR in both tests, considering the three subgroups, proved to be statistically significant (p <0.001): 0.14 +/- 0.21 (INR< 2.0); 0.54 +/- 0.31 (2.0 < or = INR < or = 3.5), and 1.64 +/- 1.10 (INR> 3.5). Paired Students t-test analysis revealed a p value < 0.001 for the three subgroups studied.
The use of point-of-care testing for monitoring oral anticoagulation has some limitations. Anticoagulation intensity was underestimated by this method in the three subgroups studied.]]></description><identifier>EISSN: 1678-4170</identifier><identifier>DOI: 10.1590/S0066-782X2007000100005</identifier><identifier>PMID: 17364115</identifier><language>eng ; por</language><publisher>Brazil</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anticoagulants - therapeutic use ; Blood Coagulation - drug effects ; Female ; Heparin, Low-Molecular-Weight - therapeutic use ; Humans ; International Normalized Ratio - methods ; Male ; Middle Aged ; Prothrombin Time ; Reference Values ; Reproducibility of Results</subject><ispartof>Arquivos brasileiros de cardiologia, 2007-01, Vol.88 (1), p.31-34</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17364115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Piano, Luciana Pereira Almeida</creatorcontrib><creatorcontrib>Strunz, Célia Maria Cássaro</creatorcontrib><creatorcontrib>Mansur, Antonio de Pádua</creatorcontrib><creatorcontrib>Rached, Roberto Abi</creatorcontrib><title>Comparison between international normalized ratio using a portable device and conventional methodology</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description><![CDATA[to compare the international normalized ratio (INR) measured by a point-of-care (POC) testing device with that measured by the conventional method in patients undergoing anticoagulation therapy with warfarin sodium.
The INR of 383 warfarin-treated patients (mean age: 56.5 years; 207 female) was measured in capillary blood using the Hemochron Jr. device and compared with that of venous plasma samples determined by the conventional method performed in a Coag-A-Mate analyzer. Results were evaluated globally and for the following subgroups: INR < 2.0, from 2.0 to 3.5, and > 3.5.
Using both methods, the comparison between INR values yielded a correlation coefficient (r) of 0.86. However, mean differences in INR in both tests, considering the three subgroups, proved to be statistically significant (p <0.001): 0.14 +/- 0.21 (INR< 2.0); 0.54 +/- 0.31 (2.0 < or = INR < or = 3.5), and 1.64 +/- 1.10 (INR> 3.5). Paired Students t-test analysis revealed a p value < 0.001 for the three subgroups studied.
The use of point-of-care testing for monitoring oral anticoagulation has some limitations. Anticoagulation intensity was underestimated by this method in the three subgroups studied.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticoagulants - therapeutic use</subject><subject>Blood Coagulation - drug effects</subject><subject>Female</subject><subject>Heparin, Low-Molecular-Weight - therapeutic use</subject><subject>Humans</subject><subject>International Normalized Ratio - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prothrombin Time</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><issn>1678-4170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LxDAQxYMg7rr6FTQnb9VJ0ibtURb_wYIHFbyVpJ2skTapSausn96K62F4w-M3A-8Rcs7gkhUVXD0BSJmpkr9yAAUAbB4oDsiSSVVmOVOwIMcpvQNwrkRxRBZMCZkzViyJXYd-0NGl4KnB8QvRU-dHjF6PLnjdUR9irzv3jS2Nvx6dkvNbqukQ4qhNh7TFT9cg1b6lTfCf6PeXPY5voQ1d2O5OyKHVXcLTva7Iy-3N8_o-2zzePayvN9nAoRoz0RYSGyGNNXMWU3LJ84pZwAZNIaTlzCiuczsnyaWyrZCiZFXOzbxBXgmxIhd_f4cYPiZMY9271GDXaY9hSrUCruYO5Aye7cHJ9NjWQ3S9jrv6vxnxA3MCZqM</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>De Piano, Luciana Pereira Almeida</creator><creator>Strunz, Célia Maria Cássaro</creator><creator>Mansur, Antonio de Pádua</creator><creator>Rached, Roberto Abi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Comparison between international normalized ratio using a portable device and conventional methodology</title><author>De Piano, Luciana Pereira Almeida ; Strunz, Célia Maria Cássaro ; Mansur, Antonio de Pádua ; Rached, Roberto Abi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-3d56ec36bfb200b8262491f0eceb536f21b72a4f002467fd36381942bd3604933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticoagulants - therapeutic use</topic><topic>Blood Coagulation - drug effects</topic><topic>Female</topic><topic>Heparin, Low-Molecular-Weight - therapeutic use</topic><topic>Humans</topic><topic>International Normalized Ratio - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prothrombin Time</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Piano, Luciana Pereira Almeida</creatorcontrib><creatorcontrib>Strunz, Célia Maria Cássaro</creatorcontrib><creatorcontrib>Mansur, Antonio de Pádua</creatorcontrib><creatorcontrib>Rached, Roberto Abi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Piano, Luciana Pereira Almeida</au><au>Strunz, Célia Maria Cássaro</au><au>Mansur, Antonio de Pádua</au><au>Rached, Roberto Abi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between international normalized ratio using a portable device and conventional methodology</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>2007-01</date><risdate>2007</risdate><volume>88</volume><issue>1</issue><spage>31</spage><epage>34</epage><pages>31-34</pages><eissn>1678-4170</eissn><abstract><![CDATA[to compare the international normalized ratio (INR) measured by a point-of-care (POC) testing device with that measured by the conventional method in patients undergoing anticoagulation therapy with warfarin sodium.
The INR of 383 warfarin-treated patients (mean age: 56.5 years; 207 female) was measured in capillary blood using the Hemochron Jr. device and compared with that of venous plasma samples determined by the conventional method performed in a Coag-A-Mate analyzer. Results were evaluated globally and for the following subgroups: INR < 2.0, from 2.0 to 3.5, and > 3.5.
Using both methods, the comparison between INR values yielded a correlation coefficient (r) of 0.86. However, mean differences in INR in both tests, considering the three subgroups, proved to be statistically significant (p <0.001): 0.14 +/- 0.21 (INR< 2.0); 0.54 +/- 0.31 (2.0 < or = INR < or = 3.5), and 1.64 +/- 1.10 (INR> 3.5). Paired Students t-test analysis revealed a p value < 0.001 for the three subgroups studied.
The use of point-of-care testing for monitoring oral anticoagulation has some limitations. Anticoagulation intensity was underestimated by this method in the three subgroups studied.]]></abstract><cop>Brazil</cop><pmid>17364115</pmid><doi>10.1590/S0066-782X2007000100005</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1678-4170 |
| ispartof | Arquivos brasileiros de cardiologia, 2007-01, Vol.88 (1), p.31-34 |
| issn | 1678-4170 |
| language | eng ; por |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Anticoagulants - therapeutic use Blood Coagulation - drug effects Female Heparin, Low-Molecular-Weight - therapeutic use Humans International Normalized Ratio - methods Male Middle Aged Prothrombin Time Reference Values Reproducibility of Results |
| title | Comparison between international normalized ratio using a portable device and conventional methodology |
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