Evidence That Calmodulin Binding to the Dopamine D2 Receptor Enhances Receptor Signaling

The Ca2+ sensor calmodulin (CaM) regulates numerous proteins involved in G protein-coupled receptor (GPCR) signaling. CaM binds directly to some GPCRs, including the dopamine D2 receptor. We confirmed that the third intracellular loop of the D2 receptor is a direct contact point for CaM binding usin...

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Veröffentlicht in:	Journal of receptors and signal transduction 2007, Vol.27 (1), p.47-65
Hauptverfasser:	LIU, YONG, BUCK, DAVID C., MACEY, TARA A., LAN, HONGXIANG, NEVE, KIM A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Amino Acid Motifs Amino Acid Sequence Binding Sites Calmodulin Calmodulin - agonists Calmodulin - metabolism Calmodulin - pharmacology Cell Line Colforsin - pharmacology Cyclic AMP - metabolism D2 Receptor Extracellular Signal-Regulated MAP Kinases - metabolism Humans Mitogen-activated protein kinase Molecular Sequence Data Neostriatum - cytology Neostriatum - metabolism Neurons - metabolism Protein:protein interaction Receptor signaling Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Signal Transduction Transfection
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