Brownian motion, fluctuation and life
The measurements of dynamic behaviors of biomolecules in relation to their functions have been allowed using single molecule measurements. Thermal Brownian motion causes random step motion of motor proteins and structural fluctuation of protein molecules between multiple states. In hierarchic struct...
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| Veröffentlicht in: | BioSystems 2007-04, Vol.88 (3), p.228-242 |
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| container_title | BioSystems |
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| creator | Yanagida, Toshio Ueda, Masahiro Murata, Tsutomu Esaki, Seiji Ishii, Yoshiharu |
| description | The measurements of dynamic behaviors of biomolecules in relation to their functions have been allowed using single molecule measurements. Thermal Brownian motion causes random step motion of motor proteins and structural fluctuation of protein molecules between multiple states. In hierarchic structure of life, the fluctuation is modulated. Random fluctuation is biased to directional motion and reactions as a result of interaction of proteins. The fluctuation of kinetic state of signaling proteins results in polarization and localization of cells. A recognition process in brain is also explained by the equation analogous to biochemical reaction at the molecular level. Thus dynamic processes originated from thermal motion may play an important role in activation processes in life. |
| doi_str_mv | 10.1016/j.biosystems.2006.08.012 |
| format | Article |
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| ispartof | BioSystems, 2007-04, Vol.88 (3), p.228-242 |
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| language | eng |
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| subjects | Actins - chemistry Actins - physiology Animals Biophysical Phenomena Biophysics Fluctuation, Brownian motion, Single molecule measurement, Molecular motor, Cell signaling process, Dynamic structure of protein, Recognition in brain Kinesin - chemistry Kinesin - physiology Models, Biological Models, Molecular Molecular Motor Proteins - chemistry Molecular Motor Proteins - physiology Motion Myosins - chemistry Myosins - physiology Protein Conformation Proteins - chemistry Proteins - physiology Signal Transduction Stochastic Processes Systems Biology Thermodynamics |
| title | Brownian motion, fluctuation and life |
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