Insulin-like growth factor-binding protein-3 inhibition of prostate cancer growth involves suppression of angiogenesis

Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein that induces apoptosis utilizing both insulin-like growth factor receptor (IGF)-dependent and -independent mechanisms. We investigated the effects of IGFBP-3 on tumor growth and angiogenesis utilizing a human CaP xen...

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Veröffentlicht in:	Oncogene 2007-03, Vol.26 (12), p.1811-1819
Hauptverfasser:	Liu, B, Lee, K-W, Anzo, M, Zhang, B, Zi, X, Tao, Y, Shiry, L, Pollak, M, Lin, S, Cohen, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Binding proteins Biological and medical sciences Cell Biology Cell Division - physiology Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Control Danio rerio Endothelial cells Fibroblast growth factors Fundamental and applied biological sciences. Psychology Genetic aspects Growth Gynecology. Andrology. Obstetrics Health aspects Human Genetics Immunodeficiency Inhibitor drugs Insulin Insulin-like growth factor 1 Insulin-Like Growth Factor Binding Protein 3 - physiology Insulin-like growth factor I Insulin-like growth factor-binding protein 3 Insulin-like growth factors Internal Medicine Male Male genital diseases Medical sciences Medicine Medicine & Public Health Mice Mice, SCID Molecular and cellular biology Mutants Neovascularization Neovascularization, Pathologic Nephrology. Urinary tract diseases Oncology original-article Physical growth Prostate cancer Prostatic Neoplasms - blood supply Prostatic Neoplasms - pathology Proteins Tumors Tumors of the urinary system Umbilical vein Urinary tract. Prostate gland Vascular endothelial growth factor Xenografts
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