Do children with lupus have fewer male siblings?

It is widely acknowledged that genetic factors play a significant role in the pathogenesis of systemic lupus erythematosus (SLE). However, the female preponderance remains unexplained. We hypothesized that the female preponderance in childhood SLE results from selection early in the course of concep...

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Veröffentlicht in:Lupus 2008-02, Vol.17 (2), p.128-131
Hauptverfasser: Moorthy, L.N., Peterson, M.G.E., Onel, K.B., Lehman, T.J.A.
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container_end_page 131
container_issue 2
container_start_page 128
container_title Lupus
container_volume 17
creator Moorthy, L.N.
Peterson, M.G.E.
Onel, K.B.
Lehman, T.J.A.
description It is widely acknowledged that genetic factors play a significant role in the pathogenesis of systemic lupus erythematosus (SLE). However, the female preponderance remains unexplained. We hypothesized that the female preponderance in childhood SLE results from selection early in the course of conception against male fetuses bearing genetic material predisposing to SLE. If this hypothesis is accurate, there should be a decreased number of male children in families with a child with SLE. Alternatively, children with SLE would have fewer male siblings. Further, this hypothesis may apply to other diseases with a female predominance such as pauciarticular onset juvenile rheumatoid arthritis (PaJRA), and not apply to diseases without female preponderance such as systemic onset juvenile rheumatoid arthritis (SoJRA). Chart review of patients with childhood onset SLE and PaJRA revealed a greater number of female children in these families compared with families of patients with SoJRA. Large-scale epidemiologic studies with precise counting of miscarriages and abortions could help to confirm these findings. Detailed studies of genetic and maternal intrauterine factors are required to conclusively prove this hypothesis. Lupus (2008) 17, 128—131.
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However, the female preponderance remains unexplained. We hypothesized that the female preponderance in childhood SLE results from selection early in the course of conception against male fetuses bearing genetic material predisposing to SLE. If this hypothesis is accurate, there should be a decreased number of male children in families with a child with SLE. Alternatively, children with SLE would have fewer male siblings. Further, this hypothesis may apply to other diseases with a female predominance such as pauciarticular onset juvenile rheumatoid arthritis (PaJRA), and not apply to diseases without female preponderance such as systemic onset juvenile rheumatoid arthritis (SoJRA). Chart review of patients with childhood onset SLE and PaJRA revealed a greater number of female children in these families compared with families of patients with SoJRA. Large-scale epidemiologic studies with precise counting of miscarriages and abortions could help to confirm these findings. 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subjects Ambulatory care
Arthritis, Juvenile - genetics
Data Interpretation, Statistical
Dentistry
Family Characteristics
Female
Females
Fetuses
Genetic Predisposition to Disease - genetics
Hospitals
Humans
Hypotheses
Immunology
Lupus
Lupus Erythematosus, Systemic - genetics
Male
Males
Missing data
Pathogenesis
Pediatrics
Retrospective Studies
Rheumatoid arthritis
Rheumatology
Sex Ratio
Siblings
Surgery
title Do children with lupus have fewer male siblings?
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