Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study
Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic...
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| Veröffentlicht in: | Veterinary dermatology 2007-04, Vol.18 (2), p.87-93 |
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| creator | Gutzwiller, Meret E. Ricklin Reist, Martin Peel, John E Seewald, Wolfgang Brunet, Laura Rosa Roosje, Petra J |
| description | Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic mycobacteria that amplify regulatory cytokines and hence the effect of Mycobacterium vaccae on the clinical severity of cAD was investigated. Sixty-two dogs with cAD, selected according to strict criteria, were treated with a single intradermal injection and evaluated monthly for 3 months in a placebo-controlled double-blind clinical trial. Clinical severity was quantified using standardized scores and by owner assessment of pruritus. A single injection of a heat-killed suspension of M. vaccae was found to be well tolerated and effective in treating mild to moderate cases of cAD demonstrable for 3 months, but was insignificant in more severely affected dogs. |
| doi_str_mv | 10.1111/j.1365-3164.2007.00579.x |
| format | Article |
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Ricklin ; Reist, Martin ; Peel, John E ; Seewald, Wolfgang ; Brunet, Laura Rosa ; Roosje, Petra J</creator><creatorcontrib>Gutzwiller, Meret E. Ricklin ; Reist, Martin ; Peel, John E ; Seewald, Wolfgang ; Brunet, Laura Rosa ; Roosje, Petra J</creatorcontrib><description>Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic mycobacteria that amplify regulatory cytokines and hence the effect of Mycobacterium vaccae on the clinical severity of cAD was investigated. Sixty-two dogs with cAD, selected according to strict criteria, were treated with a single intradermal injection and evaluated monthly for 3 months in a placebo-controlled double-blind clinical trial. Clinical severity was quantified using standardized scores and by owner assessment of pruritus. 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Ricklin</creatorcontrib><creatorcontrib>Reist, Martin</creatorcontrib><creatorcontrib>Peel, John E</creatorcontrib><creatorcontrib>Seewald, Wolfgang</creatorcontrib><creatorcontrib>Brunet, Laura Rosa</creatorcontrib><creatorcontrib>Roosje, Petra J</creatorcontrib><title>Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study</title><title>Veterinary dermatology</title><addtitle>Vet Dermatol</addtitle><description>Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic mycobacteria that amplify regulatory cytokines and hence the effect of Mycobacterium vaccae on the clinical severity of cAD was investigated. Sixty-two dogs with cAD, selected according to strict criteria, were treated with a single intradermal injection and evaluated monthly for 3 months in a placebo-controlled double-blind clinical trial. Clinical severity was quantified using standardized scores and by owner assessment of pruritus. A single injection of a heat-killed suspension of M. vaccae was found to be well tolerated and effective in treating mild to moderate cases of cAD demonstrable for 3 months, but was insignificant in more severely affected dogs.</description><subject>allergen-specific immunotherapy</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>atopic dermatitis</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Bacterial Vaccines - immunology</subject><subject>Dermatitis, Atopic - prevention & control</subject><subject>Dermatitis, Atopic - veterinary</subject><subject>disease course</subject><subject>disease severity</subject><subject>dog diseases</subject><subject>Dog Diseases - immunology</subject><subject>Dog Diseases - pathology</subject><subject>Dog Diseases - prevention & control</subject><subject>Dogs</subject><subject>dosage</subject><subject>dose response</subject><subject>Double-Blind Method</subject><subject>drug evaluation</subject><subject>drug injection</subject><subject>Female</subject><subject>immune response</subject><subject>immunomodulators</subject><subject>inactivated vaccines</subject><subject>Injections, Intradermal - veterinary</subject><subject>Male</subject><subject>Mycobacterium - immunology</subject><subject>Mycobacterium vaccae</subject><subject>Pilot Projects</subject><subject>randomized clinical trials</subject><subject>Severity of Illness Index</subject><subject>skin</subject><subject>skin lesions</subject><subject>Switzerland</subject><subject>Treatment Outcome</subject><subject>vaccination</subject><subject>Vaccines, Inactivated - administration & dosage</subject><subject>Vaccines, Inactivated - immunology</subject><issn>0959-4493</issn><issn>1365-3164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EosPAK4BX7JLajp3EiA39oVTqgCrasrQ8zk3raTIebIfOvH2dZlSW4I0t3fN9V_JBCFOS03QOVzktSpEVtOQ5I6TKCRGVzLcv0Ox58BLNiBQy41wWB-hNCCuSSCmL1-iAVoUQnLEZCufr6HUDvtcdtusVmGjdGrsW34GO2b3tOmjwYmfcUpsI3g49_qON0ZBo3LjbgB9svMM6uo01-Kko2mjDJ6xxP3TRGkgbAG9s5yIOcWh2b9GrVncB3u3vObr-enp1_C27-HF2fvzlIjNcSJlVNW-MZIJCa6q2FlRq3lLJmCnGOTGi5Y1uS1YbRioOBIDBkpdgllxDzYo5-jj1brz7PUCIqrfBQNfpNbghqIqwUhIm_gkyIqhg6evmqJ5A410IHlq18bbXfqcoUaMZtVKjADUKUKMZ9WRGbVP0_X7HsOyh-Rvcq0jA5wl4sB3s_rtY3ZycpkeKZ1Pchgjb57j296qsikqoX9_P1NXR5eLk6OZSLRL_YeJb7ZS-9Tao65-M0CJ1C17TsngEQ-a2mg</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Gutzwiller, Meret E. Ricklin</creator><creator>Reist, Martin</creator><creator>Peel, John E</creator><creator>Seewald, Wolfgang</creator><creator>Brunet, Laura Rosa</creator><creator>Roosje, Petra J</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study</title><author>Gutzwiller, Meret E. Ricklin ; Reist, Martin ; Peel, John E ; Seewald, Wolfgang ; Brunet, Laura Rosa ; Roosje, Petra J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4599-784dc9251efc7f8519a4f1922c345990c5f4daf628c2074e0ee2eb46ecb4ae823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>allergen-specific immunotherapy</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>atopic dermatitis</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Bacterial Vaccines - immunology</topic><topic>Dermatitis, Atopic - prevention & control</topic><topic>Dermatitis, Atopic - veterinary</topic><topic>disease course</topic><topic>disease severity</topic><topic>dog diseases</topic><topic>Dog Diseases - immunology</topic><topic>Dog Diseases - pathology</topic><topic>Dog Diseases - prevention & control</topic><topic>Dogs</topic><topic>dosage</topic><topic>dose response</topic><topic>Double-Blind Method</topic><topic>drug evaluation</topic><topic>drug injection</topic><topic>Female</topic><topic>immune response</topic><topic>immunomodulators</topic><topic>inactivated vaccines</topic><topic>Injections, Intradermal - veterinary</topic><topic>Male</topic><topic>Mycobacterium - immunology</topic><topic>Mycobacterium vaccae</topic><topic>Pilot Projects</topic><topic>randomized clinical trials</topic><topic>Severity of Illness Index</topic><topic>skin</topic><topic>skin lesions</topic><topic>Switzerland</topic><topic>Treatment Outcome</topic><topic>vaccination</topic><topic>Vaccines, Inactivated - administration & dosage</topic><topic>Vaccines, Inactivated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gutzwiller, Meret E. Ricklin</creatorcontrib><creatorcontrib>Reist, Martin</creatorcontrib><creatorcontrib>Peel, John E</creatorcontrib><creatorcontrib>Seewald, Wolfgang</creatorcontrib><creatorcontrib>Brunet, Laura Rosa</creatorcontrib><creatorcontrib>Roosje, Petra J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gutzwiller, Meret E. Ricklin</au><au>Reist, Martin</au><au>Peel, John E</au><au>Seewald, Wolfgang</au><au>Brunet, Laura Rosa</au><au>Roosje, Petra J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study</atitle><jtitle>Veterinary dermatology</jtitle><addtitle>Vet Dermatol</addtitle><date>2007-04</date><risdate>2007</risdate><volume>18</volume><issue>2</issue><spage>87</spage><epage>93</epage><pages>87-93</pages><issn>0959-4493</issn><eissn>1365-3164</eissn><abstract>Canine atopic dermatitis (cAD) is a common disease with a multifactorial aetiology associated with impaired immunoregulation. The immunopathogenesis has similarities to that of human atopic dermatitis. Clinical signs of allergic disease in humans and mice are reduced by administration of saprophytic mycobacteria that amplify regulatory cytokines and hence the effect of Mycobacterium vaccae on the clinical severity of cAD was investigated. Sixty-two dogs with cAD, selected according to strict criteria, were treated with a single intradermal injection and evaluated monthly for 3 months in a placebo-controlled double-blind clinical trial. Clinical severity was quantified using standardized scores and by owner assessment of pruritus. A single injection of a heat-killed suspension of M. vaccae was found to be well tolerated and effective in treating mild to moderate cases of cAD demonstrable for 3 months, but was insignificant in more severely affected dogs.</abstract><cop>Oxford, UK</cop><pub>Oxford, UK : Blackwell Publishing Ltd</pub><pmid>17355422</pmid><doi>10.1111/j.1365-3164.2007.00579.x</doi><tpages>7</tpages></addata></record> |
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| subjects | allergen-specific immunotherapy Animals anti-inflammatory activity atopic dermatitis Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Dermatitis, Atopic - prevention & control Dermatitis, Atopic - veterinary disease course disease severity dog diseases Dog Diseases - immunology Dog Diseases - pathology Dog Diseases - prevention & control Dogs dosage dose response Double-Blind Method drug evaluation drug injection Female immune response immunomodulators inactivated vaccines Injections, Intradermal - veterinary Male Mycobacterium - immunology Mycobacterium vaccae Pilot Projects randomized clinical trials Severity of Illness Index skin skin lesions Switzerland Treatment Outcome vaccination Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - immunology |
| title | Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: a multicentre pilot study |
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