Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes

Aims/hypothesis Nocturnal hypoglycaemia may contribute to sudden death in diabetic patients. However, it is not well known why hypoglycaemia makes these patients prone to death. Methods We assessed the effects of controlled hypoglycaemia on cardiac repolarisation using novel electrocardiographic des...

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Veröffentlicht in:	Diabetologia 2008-03, Vol.51 (3), p.426-435
Hauptverfasser:	Koivikko, M. L, Karsikas, M, Salmela, P. I, Tapanainen, J. S, Ruokonen, A, Seppänen, T, Huikuri, H. V, Perkiömäki, J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age of Onset Biological and medical sciences Blood Glucose - metabolism Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Electrocardiography Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epinephrine - blood Etiopathogenesis. Screening. Investigations. Target tissue resistance Euglycaemic clamp Female Glucose Glucose Clamp Technique Heart - physiopathology Heart Rate Human Physiology Humans Hypoglycaemia Hypoglycaemic clamp Hypoglycemia Hypoglycemia - physiopathology Insulin insulin-dependent diabetes mellitus Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Middle Aged Morphology Norepinephrine - blood Potassium - blood QRS complex QRS loop Repolarisation T-wave T-wave loop
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