IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

IL-33 (IL-1F11) binds ST2 (IL-1R4), both of which are associated with optimal CD4(+) Th2 polarization. Exogenous IL-33 drives induction of Th2-associated cytokines and associated pathological changes within the gut mucosa. Th2 polarization is also a prerequisite to expulsion of the intestinal-dwelli...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-02, Vol.180 (4), p.2443-2449
Hauptverfasser:	Humphreys, Neil E, Xu, Damo, Hepworth, Matthew R, Liew, Foo Y, Grencis, Richard K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Humans Immunity, Cellular - genetics Immunity, Innate - genetics Interleukin-33 Interleukins - biosynthesis Interleukins - genetics Interleukins - physiology Interleukins - therapeutic use Intestinal Diseases, Parasitic - immunology Intestinal Diseases, Parasitic - pathology Intestinal Diseases, Parasitic - prevention & control Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, SCID Nematoda Recombinant Proteins - administration & dosage Recombinant Proteins - biosynthesis Recombinant Proteins - genetics Recombinant Proteins - therapeutic use RNA, Messenger - biosynthesis Trichuriasis - immunology Trichuriasis - pathology Trichuriasis - prevention & control Trichuris - immunology
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