An Important Role for Type III Interferon (IFN-{lambda}/IL-28) in TLR-Induced Antiviral Activity

Type III IFNs (IFN-lambda/IL-28/29) are cytokines with type I IFN-like antiviral activities, which remain poorly characterized. We herein show that most cell types expressed both types I and III IFNs after TLR stimulation or virus infection, whereas the ability of cells to respond to IFN-lambda was...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-02, Vol.180 (4), p.2474-2485
Hauptverfasser:	Ank, Nina, Iversen, Marie B, Bartholdy, Christina, Staeheli, Peter, Hartmann, Rune, Jensen, Uffe B, Dagnaes-Hansen, Frederik, Thomsen, Allan R, Chen, Zhi, Haugen, Harald, Klucher, Kevin, Paludan, Soren R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - metabolism Antiviral Agents - pharmacology Crosses, Genetic Cytokines - biosynthesis Cytokines - physiology Epithelial Cells - immunology Epithelial Cells - metabolism Female Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Herpes Genitalis - immunology Herpes Genitalis - metabolism Herpes Genitalis - prevention & control Herpesvirus 2, Human - immunology Ligands Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Radiation Chimera Receptors, Cytokine - deficiency Receptors, Cytokine - genetics Toll-Like Receptors - metabolism Toll-Like Receptors - physiology
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