Conserved Metabolic Regulatory Functions of Sirtuins
Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD +) links their activity to cellular metabolic status. In bacteria, the sir...
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| Veröffentlicht in: | Cell metabolism 2008-02, Vol.7 (2), p.104-112 |
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| creator | Schwer, Bjoern Verdin, Eric |
| description | Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases/mono-ADP-ribosyltransferases found in organisms ranging from bacteria to humans. Their dependence on nicotinamide adenine dinucleotide (NAD
+) links their activity to cellular metabolic status. In bacteria, the sirtuin CobB regulates the metabolic enzyme acetyl-coenzyme A (acetyl-CoA) synthetase. The earliest function of sirtuins therefore may have been regulation of cellular metabolism in response to nutrient availability. Recent findings support the idea that sirtuins play a pivotal role in metabolic control in higher organisms, including mammals. This review surveys evidence for an emerging role of sirtuins as regulators of metabolism in mammals. |
| doi_str_mv | 10.1016/j.cmet.2007.11.006 |
| format | Article |
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| ispartof | Cell metabolism, 2008-02, Vol.7 (2), p.104-112 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetate-CoA Ligase - metabolism Animals Bacteria Humans Metabolism NAD - metabolism Sirtuins - physiology |
| title | Conserved Metabolic Regulatory Functions of Sirtuins |
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