Progressive Diastolic Dysfunction in the Female mRen(2).Lewis Rat: Influence of Salt and Ovarian Hormones
This study determined the contribution of chronic salt loading and early loss of ovarian hormones on diastolic function in the hypertensive female mRen(2).Lewis rat, a monogenetic strain that expresses the mouse renin-2 gene in various tissues. Estrogen-intact mRen2 rats fed a high salt (HS) (8% sod...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2008-01, Vol.63 (1), p.3-11 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
| container_volume | 63 |
| creator | Groban, Leanne Yamaleyeva, Liliya M. Westwood, Brian M. Houle, Timothy T. Lin, Marina Kitzman, Dalane W. Chappell, Mark C. |
| description | This study determined the contribution of chronic salt loading and early loss of ovarian hormones on diastolic function in the hypertensive female mRen(2).Lewis rat, a monogenetic strain that expresses the mouse renin-2 gene in various tissues. Estrogen-intact mRen2 rats fed a high salt (HS) (8% sodium chloride) diet exhibited early diastolic dysfunction when compared to normal salt-fed (NS) (1% sodium chloride) rats. In contrast, ovariectomized (OVX) rats on either NS or HS diets showed impaired relaxation with evidence of elevated left ventricular filling pressures (E/e′) or pseudonormalization. This more advanced stage of diastolic dysfunction was associated with increases in interstitial cardiac fibrosis and high circulating levels of aldosterone, two factors leading to reduced ventricular compliance. These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder. |
| doi_str_mv | 10.1093/gerona/63.1.3 |
| format | Article |
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Estrogen-intact mRen2 rats fed a high salt (HS) (8% sodium chloride) diet exhibited early diastolic dysfunction when compared to normal salt-fed (NS) (1% sodium chloride) rats. In contrast, ovariectomized (OVX) rats on either NS or HS diets showed impaired relaxation with evidence of elevated left ventricular filling pressures (E/e′) or pseudonormalization. This more advanced stage of diastolic dysfunction was associated with increases in interstitial cardiac fibrosis and high circulating levels of aldosterone, two factors leading to reduced ventricular compliance. These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/63.1.3</identifier><identifier>PMID: 18245755</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Age ; Aldosterone - blood ; Animals ; Blood Pressure - drug effects ; Cardiovascular disease ; Diastole - drug effects ; Estrogens - deficiency ; Estrogens - physiology ; Female ; Heart failure ; Heart Failure, Diastolic - physiopathology ; Laboratory animals ; Menopause ; Mice ; ovarian—Diastolic function—Rat ; Ovariectomy ; Rats ; Rats, Inbred Lew ; Renin ; Risk factors ; Salt—Hormone ; Sodium Chloride, Dietary - pharmacology ; Tissues ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - physiopathology ; Womens health</subject><ispartof>The journals of gerontology. 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Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>This study determined the contribution of chronic salt loading and early loss of ovarian hormones on diastolic function in the hypertensive female mRen(2).Lewis rat, a monogenetic strain that expresses the mouse renin-2 gene in various tissues. Estrogen-intact mRen2 rats fed a high salt (HS) (8% sodium chloride) diet exhibited early diastolic dysfunction when compared to normal salt-fed (NS) (1% sodium chloride) rats. In contrast, ovariectomized (OVX) rats on either NS or HS diets showed impaired relaxation with evidence of elevated left ventricular filling pressures (E/e′) or pseudonormalization. This more advanced stage of diastolic dysfunction was associated with increases in interstitial cardiac fibrosis and high circulating levels of aldosterone, two factors leading to reduced ventricular compliance. These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder.</description><subject>Age</subject><subject>Aldosterone - blood</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular disease</subject><subject>Diastole - drug effects</subject><subject>Estrogens - deficiency</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Failure, Diastolic - physiopathology</subject><subject>Laboratory animals</subject><subject>Menopause</subject><subject>Mice</subject><subject>ovarian—Diastolic function—Rat</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Renin</subject><subject>Risk factors</subject><subject>Salt—Hormone</subject><subject>Sodium Chloride, Dietary - pharmacology</subject><subject>Tissues</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Womens health</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAQgCMEog84ckUWhwoO2foR2zG3qq-t2NKqFKniYk2cSXFJ7GInpf337GpXVGIOMyPNp0-jmaJ4x-iMUSP2bzHFAPtKzNhMvCi2mZZ1KYW8ebnsqTalpFRtFTs539FVSP662GI1r6SWcrvwlyneJszZPyA58pDH2HtHjp5yNwU3-hiID2T8ieQEB-iRDFcYPvJPswX-8ZlcwfiZnIWunzA4JLEj36AfCYSWXDxA8hDIPKYhBsxvilcd9Bnfbupu8f3k-PpwXi4uTs8ODxalqzgfS6DAjZbL7NoKa16jQewUbZxkrOlapZnhUtdCQk25aQCgFbIC1lBFjRNit9hbe-9T_D1hHu3gs8O-h4BxylZTriom6BL88B94F6cUlrtZTmvFq8qsbOUacinmnLCz98kPkJ4so3b1ALt-gFXCMrvi32-kUzNg-0xvLv4s9HnEx39zSL-s0kJLO7_5Yc8vz831V1XZL-Ivk8-Qyw</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Groban, Leanne</creator><creator>Yamaleyeva, Liliya M.</creator><creator>Westwood, Brian M.</creator><creator>Houle, Timothy T.</creator><creator>Lin, Marina</creator><creator>Kitzman, Dalane W.</creator><creator>Chappell, Mark C.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Progressive Diastolic Dysfunction in the Female mRen(2).Lewis Rat: Influence of Salt and Ovarian Hormones</title><author>Groban, Leanne ; Yamaleyeva, Liliya M. ; Westwood, Brian M. ; Houle, Timothy T. ; Lin, Marina ; Kitzman, Dalane W. ; Chappell, Mark C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-a0a29750a2cd4e828e9eef60bc511bfd6719257835a8029baaad354a1b0609c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age</topic><topic>Aldosterone - blood</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular disease</topic><topic>Diastole - drug effects</topic><topic>Estrogens - deficiency</topic><topic>Estrogens - physiology</topic><topic>Female</topic><topic>Heart failure</topic><topic>Heart Failure, Diastolic - physiopathology</topic><topic>Laboratory animals</topic><topic>Menopause</topic><topic>Mice</topic><topic>ovarian—Diastolic function—Rat</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Renin</topic><topic>Risk factors</topic><topic>Salt—Hormone</topic><topic>Sodium Chloride, Dietary - pharmacology</topic><topic>Tissues</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Groban, Leanne</creatorcontrib><creatorcontrib>Yamaleyeva, Liliya M.</creatorcontrib><creatorcontrib>Westwood, Brian M.</creatorcontrib><creatorcontrib>Houle, Timothy T.</creatorcontrib><creatorcontrib>Lin, Marina</creatorcontrib><creatorcontrib>Kitzman, Dalane W.</creatorcontrib><creatorcontrib>Chappell, Mark C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. 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Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2008-01</date><risdate>2008</risdate><volume>63</volume><issue>1</issue><spage>3</spage><epage>11</epage><pages>3-11</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>This study determined the contribution of chronic salt loading and early loss of ovarian hormones on diastolic function in the hypertensive female mRen(2).Lewis rat, a monogenetic strain that expresses the mouse renin-2 gene in various tissues. Estrogen-intact mRen2 rats fed a high salt (HS) (8% sodium chloride) diet exhibited early diastolic dysfunction when compared to normal salt-fed (NS) (1% sodium chloride) rats. In contrast, ovariectomized (OVX) rats on either NS or HS diets showed impaired relaxation with evidence of elevated left ventricular filling pressures (E/e′) or pseudonormalization. This more advanced stage of diastolic dysfunction was associated with increases in interstitial cardiac fibrosis and high circulating levels of aldosterone, two factors leading to reduced ventricular compliance. These findings may explain the preponderance of diastolic dysfunction and diastolic heart failure in postmenopausal women and provide a potential animal model for evaluating prevention and treatment interventions for this disorder.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>18245755</pmid><doi>10.1093/gerona/63.1.3</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Age Aldosterone - blood Animals Blood Pressure - drug effects Cardiovascular disease Diastole - drug effects Estrogens - deficiency Estrogens - physiology Female Heart failure Heart Failure, Diastolic - physiopathology Laboratory animals Menopause Mice ovarian—Diastolic function—Rat Ovariectomy Rats Rats, Inbred Lew Renin Risk factors Salt—Hormone Sodium Chloride, Dietary - pharmacology Tissues Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - physiopathology Womens health |
| title | Progressive Diastolic Dysfunction in the Female mRen(2).Lewis Rat: Influence of Salt and Ovarian Hormones |
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