Hfe Acts in Hepatocytes to Prevent Hemochromatosis

Hereditary hemochromatosis (HH) is a prevalent, potentially fatal disorder of iron metabolism hallmarked by intestinal hyperabsorption of iron, hyperferremia, and hepatic iron overload. In both humans and mice, type I HH is associated with mutations in the broadly expressed HFE/ Hfe gene. To identif...

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Veröffentlicht in:	Cell metabolism 2008-02, Vol.7 (2), p.173-178
Hauptverfasser:	Vujić Spasić, Maja, Kiss, Judit, Herrmann, Thomas, Galy, Bruno, Martinache, Stefanie, Stolte, Jens, Gröne, Hermann-Josef, Stremmel, Wolfgang, Hentze, Matthias W., Muckenthaler, Martina U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hemochromatosis - etiology Hemochromatosis Protein Hepatocytes - metabolism Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - physiology Homeostasis HUMDISEASE Iron - metabolism Membrane Proteins - genetics Membrane Proteins - physiology Mice Mice, Mutant Strains Mutation SIGNALING
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