IL-23 Is Required for the Development of Severe Egg-Induced Immunopathology in Schistosomiasis and for Lesional Expression of IL-17

In infection with the trematode helminth Schistosoma mansoni, the severity of CD4 T cell-mediated hepatic granulomatous and fibrosing inflammation against parasite eggs varies considerably in humans and among mouse strains. In mice, either the natural high pathology, or high pathology induced by con...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2008-02, Vol.180 (4), p.2486-2495
Hauptverfasser:	Rutitzky, Laura I, Bazzone, Lindsey, Shainheit, Mara G, Joyce-Shaikh, Barbara, Cua, Daniel J, Stadecker, Miguel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Helminth - administration & dosage Antigens, Helminth - immunology Cells, Cultured Gene Expression Regulation - immunology Interleukin-17 - antagonists & inhibitors Interleukin-17 - biosynthesis Interleukin-17 - genetics Interleukin-23 Subunit p19 - deficiency Interleukin-23 Subunit p19 - genetics Interleukin-23 Subunit p19 - physiology Liver Diseases, Parasitic - immunology Liver Diseases, Parasitic - metabolism Liver Diseases, Parasitic - pathology Lymph Nodes - immunology Lymph Nodes - parasitology Lymph Nodes - pathology Mice Mice, Inbred C57BL Mice, Knockout Ovum - immunology Schistosoma mansoni Schistosoma mansoni - immunology Schistosomiasis mansoni - genetics Schistosomiasis mansoni - immunology Schistosomiasis mansoni - mortality Schistosomiasis mansoni - pathology Severity of Illness Index T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - parasitology T-Lymphocyte Subsets - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!