BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

Modifications to the non-prime side of a series of BACE-1 inhibitors are presented. This final round of optimisation led to inhibitors with nanomolar potency in a cell-based assay which were capable of lowering amyloid production in an animal model following oral administration. This article is focu...

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