4-(Dimethylamino)pyridine N-oxide (DMAPO): An Effective Nucleophilic Catalyst in the Peptide Coupling Reaction with 2-Methyl-6-nitrobenzoic Anhydride

Various carboxamides or peptides were synthesized from the corresponding carboxylic acids and amines or α‐amino acids in high yields by the catalysis of 4‐(dimethylamino)pyridine N‐oxide (DMAPO) with 2‐methyl‐6‐nitrobenzoic anhydride (MNBA). Because the segment‐coupling reaction of α‐amino acids pro...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2008-02, Vol.3 (2), p.454-461
Hauptverfasser:	Shiina, Isamu, Ushiyama, Hisaya, Yamada, Yo-ko, Kawakita, Yo-ichi, Nakata, Kenya
Format:	Artikel
Sprache:	eng
Schlagworte:	Anhydrides - chemistry carboxamides Catalysis Cyclic N-Oxides - chemistry Molecular Structure Nitrobenzoates - chemistry oligopeptides Oxides - chemical synthesis Oxides - chemistry peptide coupling peptides Peptides - chemistry synthetic methods
Online-Zugang:	Volltext
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