Differentiation between Structurally Homologous Shiga 1 and Shiga 2 Toxins by Using Synthetic Glycoconjugates

Differentiation between Structurally Homologous Shiga 1 and Shiga 2 Toxins by Using Synthetic Glycoconjugates

Choose your poison: Shiga toxins 1 and 2 are the major virulence factors of E. coli O157:H7. However, Shiga 2 is more potent than Shiga 1. Biotinylated glycoconjugates have been developed that differentiate between these structurally homologous toxins (see picture; R=OH: selective for Shiga 1; R=NHA...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2008-02, Vol.47 (7), p.1265-1268
Hauptverfasser: Kale, Ramesh R, McGannon, Colleen M, Fuller-Schaefer, Cynthia, Hatch, Duane M, Flagler, Michael J, Gamage, Shantini D, Weiss, Alison A, Iyer, Suri S
Format: Artikel
Sprache:eng
Schlagworte:
Animals
biotin
differentiation
glycoconjugates
Glycoconjugates - chemistry
glycosides
Molecular Structure
Shiga toxin
Shiga Toxin 1 - chemistry
Shiga Toxin 2 - chemistry
Spectrometry, Mass, Electrospray Ionization
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Beschreibung
Zusammenfassung:Choose your poison: Shiga toxins 1 and 2 are the major virulence factors of E. coli O157:H7. However, Shiga 2 is more potent than Shiga 1. Biotinylated glycoconjugates have been developed that differentiate between these structurally homologous toxins (see picture; R=OH: selective for Shiga 1; R=NHAc: selective for Shiga 2). These synthetic materials efficiently capture toxins without interference from the sample matrix.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200703680