The effect of diabetes and centrally administered insulin on anterior hypothalamic estrogen receptor alpha immunoreactivity

Diabetic rats have characteristic reproductive deficits. Peripheral and central (intra-cerebro-ventricular [ICV]) insulin restores the reproductive phenotype to control levels. In this experiment, we evaluated a possible defect in steroid feedback by evaluating hypothalamic estrogen receptor (ER) al...

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Veröffentlicht in:	Acta diabetologica 2007-03, Vol.44 (1), p.38-44
Hauptverfasser:	Kovacs, P, Morales, J C, Karkanias, G B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Estrogen Receptor alpha - immunology Estrogen Receptor alpha - metabolism Female Gonadotrophs - metabolism Hypothalamus, Anterior - drug effects Hypothalamus, Anterior - metabolism Hypothalamus, Anterior - pathology Immunohistochemistry Injections, Intraventricular Insulin - administration & dosage Ovariectomy Rats Rats, Sprague-Dawley Streptozocin
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