Analysis of the intracellular barriers encountered by nonviral gene carriers in a model of spatially controlled delivery to neurons

Background Neuron‐specific, nonviral gene delivery vehicles are useful tools for the potential treatment of neurological disease and spinal cord injury. For minimally invasive, peripheral administration, gene carriers must efficiently mediate uptake at axon terminals, retrograde axonal transport, ve...

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Veröffentlicht in:	The journal of gene medicine 2008-02, Vol.10 (2), p.187-197
Hauptverfasser:	Bergen, Jamie M., Pun, Suzie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport, Active - drug effects Cell Differentiation - drug effects Endocytosis - drug effects Gene therapy Gene Transfer Techniques intracellular barriers Intracellular Space - drug effects Intracellular Space - metabolism lipoplex Liposomes Nerve Growth Factor - pharmacology Neurites - drug effects neuron Neurons - cytology Neurons - drug effects Neurons - metabolism nonviral gene delivery Particle Size PC12 Cells Polyethyleneimine - metabolism polyplex Rats Transfection Transport Vesicles - drug effects Transport Vesicles - metabolism
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