Raman spectroscopic investigation of cocaine hydrochloride on human nail in a forensic context
This study describes the application of Raman spectroscopy to the detection of drugs of abuse and noncontrolled substances used in the adulteration of drugs of abuse on human nail. Contamination of the nail may result from handling or abusing these substances. Raman spectra of pure cocaine hydrochlo...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2008-02, Vol.390 (4), p.1159-1166 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Ali, Esam M. A Edwards, Howell G. M Hargreaves, Michael D Scowen, Ian J |
| description | This study describes the application of Raman spectroscopy to the detection of drugs of abuse and noncontrolled substances used in the adulteration of drugs of abuse on human nail. Contamination of the nail may result from handling or abusing these substances. Raman spectra of pure cocaine hydrochloride, a seized street sample of cocaine hydrochloride (77%), and paracetamol could be acquired from drug crystals on the surface of the nail. An added difficulty in the analytical procedure is afforded by the presence of a nail varnish coating the nail fragment. By using confocal Raman spectroscopy, spectra of the drugs under nail varnish could be acquired. Spectra of the drugs could be readily obtained nondestructively within three minutes with little or no sample preparation. Raman spectra could be acquired from drug particles with an average size of 5-20 μm. Acquisition of Raman point maps of crystals from both pure and street samples of cocaine hydrochloride under nail varnish is also reported. [graphic removed] |
| doi_str_mv | 10.1007/s00216-007-1776-z |
| format | Article |
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A ; Edwards, Howell G. M ; Hargreaves, Michael D ; Scowen, Ian J</creator><creatorcontrib>Ali, Esam M. A ; Edwards, Howell G. M ; Hargreaves, Michael D ; Scowen, Ian J</creatorcontrib><description>This study describes the application of Raman spectroscopy to the detection of drugs of abuse and noncontrolled substances used in the adulteration of drugs of abuse on human nail. Contamination of the nail may result from handling or abusing these substances. Raman spectra of pure cocaine hydrochloride, a seized street sample of cocaine hydrochloride (77%), and paracetamol could be acquired from drug crystals on the surface of the nail. An added difficulty in the analytical procedure is afforded by the presence of a nail varnish coating the nail fragment. By using confocal Raman spectroscopy, spectra of the drugs under nail varnish could be acquired. Spectra of the drugs could be readily obtained nondestructively within three minutes with little or no sample preparation. Raman spectra could be acquired from drug particles with an average size of 5-20 μm. Acquisition of Raman point maps of crystals from both pure and street samples of cocaine hydrochloride under nail varnish is also reported. 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A</creatorcontrib><creatorcontrib>Edwards, Howell G. M</creatorcontrib><creatorcontrib>Hargreaves, Michael D</creatorcontrib><creatorcontrib>Scowen, Ian J</creatorcontrib><title>Raman spectroscopic investigation of cocaine hydrochloride on human nail in a forensic context</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>This study describes the application of Raman spectroscopy to the detection of drugs of abuse and noncontrolled substances used in the adulteration of drugs of abuse on human nail. Contamination of the nail may result from handling or abusing these substances. Raman spectra of pure cocaine hydrochloride, a seized street sample of cocaine hydrochloride (77%), and paracetamol could be acquired from drug crystals on the surface of the nail. An added difficulty in the analytical procedure is afforded by the presence of a nail varnish coating the nail fragment. By using confocal Raman spectroscopy, spectra of the drugs under nail varnish could be acquired. Spectra of the drugs could be readily obtained nondestructively within three minutes with little or no sample preparation. Raman spectra could be acquired from drug particles with an average size of 5-20 μm. Acquisition of Raman point maps of crystals from both pure and street samples of cocaine hydrochloride under nail varnish is also reported. [graphic removed]</description><subject>Acetaminophen - analysis</subject><subject>Analytical Chemistry</subject><subject>Biochemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cocaine - analysis</subject><subject>Cocaine hydrochloride</subject><subject>Food Science</subject><subject>Forensic Medicine</subject><subject>Forensics</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Monitoring/Environmental Analysis</subject><subject>nails (primates)</subject><subject>Nails - chemistry</subject><subject>Original Paper</subject><subject>Raman spectroscopy</subject><subject>Spectrum Analysis, Raman - methods</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9v1DAQxS1ERUvhA3CBnLgFZuzEcY6o4k-lSki0vWI5znjXVdZe7KSi_fT1Kiu4wWmeNO-9Gf0Ye4PwAQG6jxmAo6yLrLHrZP34jJ2hRFVz2cLzP7rhp-xlzncA2CqUL9gpKuy45HjGfv4wOxOqvCc7p5ht3Htb-XBPefYbM_sYqugqG63xgartw5ii3U4x-ZGqstsuh3QwfiqhylQuJgq5VNgYZvo9v2InzkyZXh_nObv98vnm4lt99f3r5cWnq9o2Usx100qg1klheqEGhXbgQ9Njb0VDox3sIByAc8aB65WlkZxouDKNoUGg4yDO2fu1d5_ir6U8r3c-W5omEyguWXfAJahy639GwVGotuuLEVejLVhyIqf3ye9MetAI-kBfr_T1QR7o68eSeXssX4YdjX8TR9zFwFdDLquwoaTv4pJCIfPP1ndryJmozSb5rG-vOaAAUK3EphVPYYmbdQ</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Ali, Esam M. 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acetaminophen - analysis Analytical Chemistry Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Cocaine - analysis Cocaine hydrochloride Food Science Forensic Medicine Forensics Humans Laboratory Medicine Monitoring/Environmental Analysis nails (primates) Nails - chemistry Original Paper Raman spectroscopy Spectrum Analysis, Raman - methods |
| title | Raman spectroscopic investigation of cocaine hydrochloride on human nail in a forensic context |
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