Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population

Abstract Insulin-degrading enzyme (IDE) is a metalloproteinase which degrades insulin and terminates its action. Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a rat model of type 2 diabetes mellitus. Several genetic association studies examined IDE as a susc...

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Veröffentlicht in:	Diabetes research and clinical practice 2008-02, Vol.79 (2), p.284-290
Hauptverfasser:	Kwak, S.H, Cho, Y.M, Moon, M.K, Kim, J.H, Park, B.L, Cheong, H.S, Shin, H.D, Jang, H.C, Kim, S.Y, Lee, H.K, Park, K.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Chromosome Mapping Chromosomes, Human, Pair 10 Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Endocrinology & Metabolism Female Genetic Predisposition to Disease Genetic Variation Humans Insulin-degrading enzyme Insulysin - genetics Korea - epidemiology Male Middle Aged Polymorphism Polymorphism, Single Nucleotide Reference Values Risk Assessment Type 2 diabetes mellitus
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